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| Product Name: | KI-7 | | Synonyms: | KI-7;1H-Indole-3-acetamide, α-oxo-N-phenyl-1-(phenylmethyl)-;KI-74;potentiate,Runx2,Osterix,KI7,KI 7,Inhibitor,P1 receptor,inhibit,orthosteric,MSC,cAMP,accumulation,KI-7,Adenosine Receptor,allosteric;2-(1-Benzyl-1H-indol-3-yl)-2-oxo-N-phenylacetamide;KI-7, 10 mM in DMSO | | CAS: | 1489263-00-4 | | MF: | C23H18N2O2 | | MW: | 354.41 | | EINECS: | | | Product Categories: | | | Mol File: | 1489263-00-4.mol |  |
| density | 1.18±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 10.93±0.70(Predicted) | | form | Solid | | color | White to off-white |
| Uses | KI-7 is an A2B adenosine receptor positive allosteric modulator. KI-7 potentiates the cAMP accumulation induced by the non-selective A2B adenosine receptor agonist NECA (EC50=445.8 nM). KI-7 also potentiates the cAMP accumulation induced by the selective A2B adenosine receptor agonist BAY 60-6583 as well as by adenosine with EC50s of 2390 nM and 2550 nM, respectively[1][2]. | | storage | Store at +4°C | | References | [1] Trincavelli ML, et al. Allosteric modulators of human A2B adenosine receptor. Biochim Biophys Acta. 2014;1840(3):1194-1203. DOI:10.1016/j.bbagen.2013.12.021
[2] Trincavelli ML, et al. Osteoblast differentiation and survival: A role for A2B adenosine receptor allosteric modulators. Biochim Biophys Acta. 2014;1843(12):2957-2966. DOI:10.1016/j.bbamcr.2014.09.013 |
| | KI-7 Preparation Products And Raw materials |
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