- azd4635
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- $0.00 / 1gram
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2025-12-25
- CAS:1321514-06-0
- Min. Order: 1gram
- Purity: 99%
- Supply Ability: 10kg
- azd4635
-
- $7.00 / 1KG
-
2020-02-14
- CAS: 1321514-06-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
- azd4635
-
- $7.00 / 1KG
-
2020-02-14
- CAS: 1321514-06-0
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 100kg
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| | azd4635 Basic information |
| Product Name: | azd4635 | | Synonyms: | azd4635;HTL-1071;CPD1545;6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine;1,2,4-Triazin-3-amine, 6-(2-chloro-6-methyl-4-pyridinyl)-5-(4-fluorophenyl)-;AZD-4635; HTL-1071;AZD-4635; AZD 4635; AZD4635; HTL-1071; HTL 1071; HTL1071;CS-2744 | | CAS: | 1321514-06-0 | | MF: | C15H11ClFN5 | | MW: | 315.73 | | EINECS: | | | Product Categories: | APIs | | Mol File: | 1321514-06-0.mol |  |
| | azd4635 Chemical Properties |
| Boiling point | 491.5±55.0 °C(Predicted) | | density | 1.387±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO:56.65(Max Conc. mg/mL);179.42(Max Conc. mM)
DMSO:PBS(pH 7.2) (1:3):0.25(Max Conc. mg/mL);0.79(Max Conc. mM)
DMF:30.0(Max Conc. mg/mL);95.01(Max Conc. mM) | | form | A crystalline solid | | pka | 1.75±0.63(Predicted) | | color | Off-white to yellow | | InChI | InChI=1S/C15H11ClFN5/c1-8-6-10(7-12(16)19-8)14-13(20-15(18)22-21-14)9-2-4-11(17)5-3-9/h2-7H,1H3,(H2,18,20,22) | | InChIKey | NCWQLHHDGDXIJN-UHFFFAOYSA-N | | SMILES | N1C(C2C=C(C)N=C(Cl)C=2)=C(C2=CC=C(F)C=C2)N=C(N)N=1 |
| | azd4635 Usage And Synthesis |
| Uses | AZD4635, is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM. | | Synthesis | 6-Bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine (1 mole-equivalent), 2-chloro-6-methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine (1 mole-equivalent), and K2CO3 (1.5 mole-equivalent) were used as raw materials suspended in a solvent mixture of 1,4-dioxane and water (v/v ratio 2 :1; 10 mL solvent/g 6-bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine). The mixture was degassed and dichlorobis[bis(4-dimethylaminophenyl)phosphino]palladium(II) (2 mol%) was added as a catalyst, and the reaction was heated and refluxed until complete consumption of 6-bromo-5-(4-fluorophenyl)-1,2,4-triazin-3-amine was confirmed by LCMS monitoring. Upon completion of the reaction, the reaction mixture was cooled, diluted with water, extracted with dichloromethane and the organic phase was separated by a phase separator. The organic phase was concentrated under reduced pressure and purified by gradient fast chromatography using a mixture of ethyl acetate and hexane solvents as eluent to give the final target product 6-(2-chloro-6-methylpyridin-4-yl)-5-(4-fluorophenyl)-1,2,4-triazin-3-amine in 61% yield. | | References | [1] Patent: WO2011/95625, 2011, A1. Location in patent: Page/Page column 177 |
| | azd4635 Preparation Products And Raw materials |
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