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Quinelorane 2HCl manufacturers
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| | Quinelorane 2HCl Basic information |
| Product Name: | Quinelorane 2HCl | | Synonyms: | Quinelorane hydrochloride;(5aR,9aR)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido[2,3-g]quinazolin-2-aminedihydrochloride;QUINELORANE DIHYDROCHLORIDE (LY-163,502) D2 DOPAMINE RECEPTOR;LY-163,502, (5aR-trans)-5,5a,6,7,8,9,9a,10-Octahydro-6-propylpyrido[2,3-g]quinazolin-2-amine dihydrochloride;Quinelorane 2HCl | | CAS: | 97548-97-5 | | MF: | C14H23ClN4 | | MW: | 282.82 | | EINECS: | | | Product Categories: | | | Mol File: | 97548-97-5.mol |  |
| | Quinelorane 2HCl Chemical Properties |
| storage temp. | Desiccate at RT | | solubility | H2O: >10mg/mL | | form | Powder | | color | white | | Water Solubility | Soluble to 25 mM in water |
| | Quinelorane 2HCl Usage And Synthesis |
| Uses | Antihypertensive; antiparkinsonian. | | Uses | Quinelorane Dihydrochloride is a D2DR agonist. | | Biological Activity | Dopamine D 2 and D 3 receptor agonist; K i values are 5.7 and 3.4 nM respectively. | | in vivo | Quinelorane dihydrochloride (LY163502; 0.003, 0.01 mg/kg; s.c.) reduces GABA efflux, with significant effects with 0.01 but not 0.003 mg/kg in male Wistar rats (300 g)[1].
Quinelorane dihydrochloride (0.032, 0.32, 3.2, 5.6 mg/kg; IP) significantly and dose-dependently increases locomotor activity in the Sprague Dawley rats. There was no main effect of sex and sex interaction[1].
Quinelorane dihydrochloride significantly decreases activity in the male and female inbred FVB/NJ, BALB/cJ, BALB/cByJ, C57BL/6J, Swiss Webster, A/J, DBA/2J, 129S1/SvImJ, and 129S6/SvEvTac mice[1].
| | IC 50 | D2 Receptor; D3 Receptor | | storage | Desiccate at RT |
| | Quinelorane 2HCl Preparation Products And Raw materials |
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