| Company Name: |
Zhengzhou HSH Science & Technology Co., Ltd.
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| Tel: |
0371-55932928 18937192232; |
| Email: |
1282296214@qq.com |
| Products Intro: |
Product Name:2-((tert-Butoxycarbonyl)amino)-3-(naphthalen-2-yl)propanoic acid
CAS:56583-58-5
Purity:96% Package:10KG;1KG;100G;50G;10G;5G;1G
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| Company Name: |
LABTER PHARMATECH(BEIJING) CO.,LTD
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| Tel: |
010-56330744 18310155299 |
| Email: |
sales@labter.com.cn |
| Products Intro: |
Product Name:2-TERT-BUTOXYCARBONYLAMINO-3-NAPHTHALEN-2-YL-PROPIONIC ACID
CAS:56583-58-5
Purity:95% HPLC Package:1g;5g;10g;25g;100g
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| | N-T-BOC-D-3-(2-NAPHTHYL)ALANINE Basic information |
| | N-T-BOC-D-3-(2-NAPHTHYL)ALANINE Chemical Properties |
| Boiling point | 512.184±43.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.200±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | −20°C | | pka | 3.881±0.30(predicted) | | Appearance | White to off-white Solid |
| | N-T-BOC-D-3-(2-NAPHTHYL)ALANINE Usage And Synthesis |
| Synthesis | 1. N-Boc-L-3-(2-naphthyl)alanine (0.43 g, 2.0 mmol) was dissolved in a solvent mixture of dioxane (8 ml), water (8 ml) and triethylamine (4 ml).
2. BOC-ON (0.49 g, 2.0 mmol) was added and the reaction mixture was stirred overnight at room temperature under argon protection.
3. After completion of the reaction, water (30 ml) was added for dilution and extracted with ethyl acetate (3 x 20 ml).
4. The aqueous layer was acidified to pH=4 with 10% citric acid solution and extracted again with ethyl acetate (3 x 20 ml).
5. The organic phases were combined, dried over anhydrous magnesium sulfate and concentrated under reduced pressure to give a colorless oily product (0.52 g, 82% yield).
6. The product was characterized by 1H NMR (DMSO-d6): δ 7.8 (3H, m), 7.7 (1H, s), 7.4 (3H, m), 7.15 (1H, d), 4.2 (1H, m), 3.2 (1H, m), 2.9 (1H, m), 1.3 (9H, s). | | References | [1] Patent: US5486597, 1996, A |
| | N-T-BOC-D-3-(2-NAPHTHYL)ALANINE Preparation Products And Raw materials |
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