| Company Name: |
BOC Sciences |
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
LHF-535 manufacturers
- LHF-535
-
- $39.00
-
2026-07-17
- CAS:1450929-77-7
- Purity: 99.90%
- Supply Ability: 10g
- LHF-535
-
- $39.00
-
2026-07-17
- CAS:1450929-77-7
- Purity: 99.90%
- Supply Ability: 10g
|
| | LHF-535 Basic information |
| Product Name: | LHF-535 | | Synonyms: | LHF-535;Benzenemethanol, a,a-dimethyl-4-[(1Z)-2-[1-[4-(1-methylethoxy)phenyl]-1H-benzimidazol-5-yl]ethenyl]-;inhibit,LHF-535,Arenavirus,LHF 535,Inhibitor,LHF535;Benzenemethanol, α,α-dimethyl-4-[(1Z)-2-[1-[4-(1-methylethoxy)phenyl]-1H-benzimidazol-5-yl]ethenyl]-;LHF-535, 10 mM in DMSO;(Z)-2-(4-(2-(1-(4-Isopropoxyphenyl)-1H-benzo[d]imidazol-5-yl)vinyl)phenyl)propan-2-ol | | CAS: | 1450929-77-7 | | MF: | C27H28N2O2 | | MW: | 412.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1450929-77-7.mol |  |
| | LHF-535 Chemical Properties |
| Boiling point | 597.9±52.0 °C(Predicted) | | density | 1.10±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : 96.67 mg/mL (234.34 mM; Need ultrasonic) | | form | Solid | | pka | 14.46±0.29(Predicted) | | color | Light yellow to yellow |
| | LHF-535 Usage And Synthesis |
| Uses | LHF-535 is an antiviral agent extracted from patent WO2013123215A2, Compound 38, has EC50s of <1 μM, <1 μM, <1 μM, and 1-10 μM for Lassa, Machupo, Junin, and VSVg virus, respectively[1]. | | in vivo | LHF-535 (3, 10 or 30 mg/kg; orally; daily; 14 days) protectes mice from a lethal challenge with Tacaribe virus and dramatically reduces viral titers in plasma, spleen, and liver[2].
An increase in survival is also observed when the first dose of LHF-535 (10 mg/kg) is delayed by 1, 2, or 3 days after infection in mice[2]. | Animal Model: | IFN-α/β and-γ receptor-deficient AG129 mice[2] | | Dosage: | 3, 10, or 30 mg/kg/day | | Administration: | Orally; daily; 14 days | | Result: | Effective as a post-exposure therapeutic. |
| | References | [1] Dongcheng Dai, et al. Antiviral drugs for treatment of arenavirus infection. WO2013123215A2.
[2] Madu IG, et al. A potent Lassa virus antiviral targets an arenavirus virulence determinant. PLoS Pathog. 2018 Dec 21;14(12):e1007439. DOI:10.1371/journal.ppat.1007439 |
| | LHF-535 Preparation Products And Raw materials |
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