| Company Name: |
Shanghai Universal Biotech Co.,Ltd
|
| Tel: |
15921930842 15921930842 |
| Email: |
yh-wang@univ-bio.com |
| Products Intro: |
Product Name:HER2/ErbB2 (29D8) Rabbit mAb
Purity:见优宁维官网 Package:100ul/RMB 10
|
| Company Name: |
Cell Signaling Technology Inc
|
| Tel: |
21-80243558 86218024 |
| Email: |
info@cellsignal.cn |
| Products Intro: |
Product Name:HER2/ErbB2 (29D8) Rabbit mAb
|
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| | HER2/ErbB2 (29D8) Rabbit mAb Chemical Properties |
| | HER2/ErbB2 (29D8) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse | | Background | The ErbB2 proto-oncogene encodes a 185 kDa transmembrane, receptor-like glycoprotein with intrinsic tyrosine kinase activity. While ErbB2 lacks an identified ligand, ErbB2 kinase activity can be activated in the absence of a ligand when overexpressed and through heteromeric associations with other ErbB family members. Amplification of the ErbB2 gene and overexpression of its product are detected in almost 40% of human breast cancers. Binding of the c-Cbl ubiquitin ligase to ErbB2 at Tyr1112 leads to ErbB2 poly-ubiquitination and enhances degradation of this kinase. ErbB2 is a key therapeutic target in the treatment of breast cancer and other carcinomas and targeting the regulation of ErbB2 degradation by the c-Cbl-regulated proteolytic pathway is one potential therapeutic strategy. Phosphorylation of the kinase domain residue Tyr877 of ErbB2 may be involved in regulating ErbB2 biological activity. The major autophosphorylation sites in ErbB2 are Tyr1248 and Tyr1221/1222; phosphorylation of these sites couples ErbB2 to the Ras-Raf-MAP kinase signal transduction pathway. | | References | [1] Muthuswamy, S.K. et al. (1999) Mol Cell Biol 19, 6845-57.
[2] Qian, X. et al. (1994) Proc Natl Acad Sci USA 91, 1500-4.
[3] Dittadi, R. and Gion, M. (2000) J Natl Cancer Inst 92, 1443-4.
[4] Klapper, L.N. et al. (2000) Cancer Res 60, 3384-8.
[5] Kwon, Y.K. et al. (1997) J Neurosci 17, 8293-9. |
| | HER2/ErbB2 (29D8) Rabbit mAb Preparation Products And Raw materials |
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