| Company Name: |
Shanghai Universal Biotech Co.,Ltd
|
| Tel: |
15921930842 15921930842 |
| Email: |
yh-wang@univ-bio.com |
| Products Intro: |
Product Name:PI3 Kinase p85 (19H8) Rabbit mAb
Purity:见优宁维官网 Package:100ul/RMB 10
|
| Company Name: |
Cell Signaling Technology Inc
|
| Tel: |
21-80243558 86218024 |
| Email: |
info@cellsignal.cn |
| Products Intro: |
Product Name:PI3 Kinase p85 (19H8) Rabbit mAb
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| | PI3 Kinase p85 (19H8) Rabbit mAb Chemical Properties |
| | PI3 Kinase p85 (19H8) Rabbit mAb Usage And Synthesis |
| Source | Rabbit | | Reactivity | Human;Mouse;Rat | | Background | Phosphoinositide 3-kinase catalyzes the production of phosphatidylinositol-3,4,5-triphosphate by phosphorylating phosphatidylinositol, phosphatidylinositol-4-phosphate, and phosphatidylinositol-4,5-bisphosphate. Growth factors and hormones trigger this phosphorylation event, which in turn coordinates cell growth, cell cycle entry, cell migration, and cell survival. PTEN reverses this process, and research studies have shown that the PI3K signaling pathway is constitutively activated in human cancers that have loss of function of PTEN. PI3Ks are composed of a catalytic subunit and a regulatory subunit. Various isoforms of the catalytic subunit have been isolated, and the regulatory subunits that associate with p110α, p110β, and p110δ are p85α and p85β. In contrast, p110γ associates with a p101 regulatory subunit that is unrelated to p85. Furthermore, p110γ is activated by βγ subunits of heterotrimeric G proteins. | | References | [1] Cantley, L.C. (2002) Science 296, 1655-7.
[2] Simpson, L. and Parsons, R. (2001) Exp Cell Res 264, 29-41.
[3] Neri, L.M. et al. (2002) Biochim Biophys Acta 1584, 73-80.
[4] Stoyanov, B. et al. (1995) Science 269, 690-3. |
| | PI3 Kinase p85 (19H8) Rabbit mAb Preparation Products And Raw materials |
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