| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:AcLys-PABC-VC-Aur0101
CAS:1438851-17-2
Package:100mg;500mg
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| Company Name: |
Anhui JYHX CO., LTD.
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| Tel: |
055167162561 13295518198 |
| Email: |
wangyanan@ahjyhx.com |
| Products Intro: |
CAS:1438851-17-2
Purity:95% 97% 98% HPLC Package:MG;G;10G;100G;500G;1kg;100kg;1000kg
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| | AcLys-PABC-VC-Aur0101 Basic information |
| Product Name: | AcLys-PABC-VC-Aur0101 | | Synonyms: | AcLys-PABC-VC-Aur0101;L-Valinamide, N-[[[4-[[N2-acetyl-L-lysyl-L-valyl-N5-(aminocarbonyl)-L-ornithyl]amino]phenyl]methoxy]carbonyl]-2-methylalanyl-N-[(1S,2R)-2-methoxy-4-[(2S)-2-[(1R,2R)-1-methoxy-2-methyl-3-oxo-3-[[(1S)-2-phenyl-1-(2-thiazolyl)ethyl]amino]propyl]-1-pyrrolidinyl]-1-[(1S)-1-methylpropyl]-4-oxobutyl]-N-met... | | CAS: | 1438851-17-2 | | MF: | C66H103N13O13S | | MW: | 1318.69 | | EINECS: | | | Product Categories: | | | Mol File: | 1438851-17-2.mol |  |
| | AcLys-PABC-VC-Aur0101 Chemical Properties |
| Boiling point | 1395.2±65.0 °C(Predicted) | | density | 1.200±0.06 g/cm3(Predicted) | | pka | 10.56±0.46(Predicted) | | form | Solid | | color | White to off-white |
| | AcLys-PABC-VC-Aur0101 Usage And Synthesis |
| Uses | AcLys-PABC-VC-Aur0101 is a agent-linker conjugate for ADC (anti-CXCR4 ADC) with potent antitumor activity by using Aur0101 (an auristatin microtubule inhibitor), linked via the cleavable linker AcLys-PABC-VC[1]. | | IC 50 | Auristatin | | References | [1] Costa MJ, et al. Optimal design, anti-tumour efficacy and tolerability of anti-CXCR4 antibody drug conjugates. Sci Rep. 2019 Feb 21;9(1):2443. DOI:10.1038/s41598-019-38745-x |
| | AcLys-PABC-VC-Aur0101 Preparation Products And Raw materials |
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