| Company Name: |
Shanghai YuanYe Biotechnology Co., Ltd.
|
| Tel: |
13636370518 |
| Email: |
shyysw007@163.com |
| Products Intro: |
Product Name:Sigma-1 receptor antagonist 3
CAS:1639220-17-9
Package:1ml Remarks:T96312
|
| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
|
| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:Sigma-1 receptor antagonist 3
CAS:1639220-17-9
Purity:≥98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
|
| Company Name: |
Fan De(Beijing) Biotechnology Co., Ltd.
|
| Tel: |
15911056312 |
| Email: |
liming@bio-fount.com |
| Products Intro: |
Product Name:Sigma-1 receptor antagonist 3
CAS:1639220-17-9
Purity:97.0% Package:5mg
|
Sigma-1 receptor antagonist 3 manufacturers
|
| | Sigma-1 receptor antagonist 3 Basic information |
| Product Name: | Sigma-1 receptor antagonist 3 | | Synonyms: | Sigma-1 receptor antagonist 3;Pyrimidine, 5-chloro-2-(4-fluorophenyl)-4-methyl-6-[3-(1-piperidinyl)propoxy]-;KcsA,Potassium Channel,inhibit,Sigma-1 receptor antagonist 3,Sigma 1 receptor antagonist 3,Inhibitor,Sigma Receptor,Sigma1 receptor antagonist 3;5-Chloro-2-(4-fluorophenyl)-4-methyl-6-(3-(piperidin-1-yl)propoxy)pyrimidine;Si ma-1 receptor anta onist 3;Sigma-1 receptor antagonist 3, 10 mM in DMSO;5-?Chloro-?2-?(4-?fluorophenyl)?-?4-?methyl-?6-?[3-?(1-?piperidinyl)?propoxy]?-pyrimidine | | CAS: | 1639220-17-9 | | MF: | C19H23ClFN3O | | MW: | 363.86 | | EINECS: | | | Product Categories: | | | Mol File: | 1639220-17-9.mol |  |
| | Sigma-1 receptor antagonist 3 Chemical Properties |
| Boiling point | 415.9±45.0 °C(Predicted) | | density | 1.196±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO: 12.5 mg/mL (34.35 mM) | | pka | 8.95±0.10(Predicted) | | form | Solid | | color | White to off-white |
| | Sigma-1 receptor antagonist 3 Usage And Synthesis |
| Uses | Sigma-1 receptor antagonist 3 (compound135) is a potent and selective Sigma-1 (σ1) receptor antagonist with a Ki of 1.14 nM. Sigma-1 receptor antagonist 3 inhibits Human Ether-a-go-go-Related Gene (hERG) with an IC50 of 1.54 μM. Sigma-1 receptor antagonist 3 has the potential for the neuropathic pain[1]. | | IC 50 | Sigma 1 Receptor | | References | [1] Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23. DOI:10.1021/jm501207r |
| | Sigma-1 receptor antagonist 3 Preparation Products And Raw materials |
|