2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate

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2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate Suppliers list
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2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate manufacturers

  • PF-06882961 Tris
  • PF-06882961 Tris pictures
  • $133.00
  • 2026-09-10
  • CAS:2230198-03-3
  • Purity: 98.74%
  • Supply Ability: 10g
2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate Basic information
Product Name:2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate
Synonyms:2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate;PF-06882961-82;UNII-2HJV78O0SS;PF-06882961 tromethamine;PF 06882961 Tris,PF06882961 Tris;2-[[4-[6-[(4-cyano-2-fluoro-phenyl)methoxy]-2-pyridyl]-1-piperidyl]methyl]-3-[[(2S)-oxetan-2-yl]methyl]benzimidazole-5-carboxylic acid;2-amino-2-(hydroxymethyl)propane-1,3-diol 2-[[4-[6-[(4-cyano-2-fluoro-phenyl)methoxy]-2-pyridyl]-1-piperidyl]methyl]-3-[[(2S)-oxetan-2-yl]methyl]benzimidazole-5-carboxylic acid;Danuglipron tromethamine
CAS:2230198-03-3
MF:C35H41FN6O7
MW:676.75
EINECS:
Product Categories:
Mol File:2230198-03-3.mol
2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate Structure
2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate Chemical Properties
InChIKeyJEJPAGACGZQFHN-NETKZVBLNA-N
SMILESC(N)(CO)(CO)CO.C([C@H]1OCC1)N1C(=NC2=CC=C(C(=O)O)C=C12)CN1CCC(C2=CC=CC(OCC3C=CC(C#N)=CC=3F)=N2)CC1 |&1:9,r|
Safety Information
MSDS Information
2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate Usage And Synthesis
UsesDanuglipron (PF-06882961) tromethamine is an orally active glucagon-like peptide-1 receptor (GLP-1R) agonist. Danuglipron tromethamine has the potential for type 2 diabetes research[1][2].
in vivo

Danuglipron (PF-06882961; 10 mg/kg; po; a single dose) tromethamine reduces blood glucose levels following intraperitoneal glucose tolerance test (IPGTT) in the hGLP-1R mouse model[2].
Pharmacokinetic Parameters of Danuglipron in Male Wistar rats and Male cynomolgus monkeys[1].

1.19
SpeciesDose (mg/kg)Cmax (ng/mL)Tmax (h)AUC0–∞ (ng h/mL)CLp (mL/min/kg)Vdss (L/kg)t1/2 (h)Oral F (%)
rat1.0 (iv)--296 ± 39.857.3 ± 8.680.86 ± 0.381.13 ± 0.84 -
rat5.0 (po)1410.5168--0.6311
rat100 (po)28200.7511900--2.3739
monkey1.0 (iv)--124013.80.2661.89-
monkey5.0 (po)68.71.5303--6.925.0
monkey100 (po)1150 ± 715 3.3 ± 2.511000 ± 3500--6.379.0
Animal Model:C57BL/6 mice expressing humanized GLP-1R[2]
Dosage:10 mg/kg
Administration:po; a single dose
Result:Lowered blood glucose levels following IPGTT.
References[1] David A Griffithm, et al. A Small-Molecule Oral Agonist of the Human Glucagon-like Peptide-1 Receptor. J Med Chem. 2022 Jun 23;65(12):8208-8226. DOI:10.1021/acs.jmedchem.1c01856
[2] W. GUO, et al. Preclinical pharmacology of low molecular weight GLP-1 receptor agonist XW014.
2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate Preparation Products And Raw materials
Tag:2-amino-2-(hydroxymethyl)propane-1,3-diol (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate(2230198-03-3) Related Product Information
1H-Benzimidazole-6-carboxylic acid, 2-[[4-[6-[(4-cyano-2-fluorophenyl)methoxy]-2-pyridinyl]-1-piperidinyl]methyl]-1-(2-oxetanylmethyl)- methyl (S)-2-((4-(6-((4-cyano-2-fluorobenzyl)oxy)pyridin-2-yl)piperidin-1-yl)methyl)-1-(oxetan-2-ylmethyl)-1H-benzo[d]imidazole-6-carboxylate 1H-Benzimidazole-6-carboxylic acid, 2-[[4-[6-[(2-cyclopropylpyrazolo[1,5-a]pyridin-6-yl)methoxy]-2-pyridinyl]-1-piperidinyl]methyl]-1-[(2S)-2-oxetanylmethyl]- 1H-Benzimidazole-6-carboxylic acid, 2-[[6-[(4-cyano-2-fluorophenyl)methoxy]-3',6'-dihydro[2,4'-bipyridin]-1'(2'H)-yl]methyl]-1-[(2S)-2-oxetanylmethyl]- 2-[(1S)-1-[4-[6-[(4-Cyano-2-fluorophenyl)methoxy]-2-pyridinyl]-1-piperazinyl]ethyl]-1-[(2S)-2-oxetanylmethyl]-1H-benzimidazole-6-carboxylic acid PF-06882961