| Company Name: |
Shanghai Hongye Biotechnology Co. Ltd
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| Tel: |
400-9205774 |
| Email: |
sales@glpbio.cn |
| Products Intro: |
Product Name:tetranor-12(S)-HETE
CAS:121842-79-3
Purity:>98% Package:1mg;10mg;50mg;100mg;
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| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:tetranor-12(S)-HETE
CAS:121842-79-3
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| Company Name: |
MedBioPharmaceutical Technology Inc
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| Tel: |
021-69568360 18916172912 |
| Email: |
order@med-bio.cn |
| Products Intro: |
Product Name:TETRANOR-12(S)-HETE
CAS:121842-79-3
Purity:98% Package:100ug (solution); 25ug (solution); 50ug (solution) Remarks:Medbio
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| Company Name: |
TargetMol Chemicals Inc.
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| Tel: |
4008200310 15002144251 |
| Email: |
marketing@tsbiochem.com |
| Products Intro: |
Product Name:tetranor-12(S)-HETE
CAS:121842-79-3
Package:100μg/RMB 14300
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TETRANOR-12(S)-HETE manufacturers
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| | TETRANOR-12(S)-HETE Basic information |
| Product Name: | TETRANOR-12(S)-HETE | | Synonyms: | TETRANOR-12(S)-HETE;KBOVKDIBOBQLRS-ONCCEEIJSA-N;4,6,10-Hexadecatrienoic acid, 8-hydroxy-, [S-(E,Z,Z)]- (9CI) | | CAS: | 121842-79-3 | | MF: | C16H26O3 | | MW: | 266.38 | | EINECS: | | | Product Categories: | | | Mol File: | 121842-79-3.mol |  |
| | TETRANOR-12(S)-HETE Chemical Properties |
| storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): .5 mg/ml |
| | TETRANOR-12(S)-HETE Usage And Synthesis |
| Description | 12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas. In some diseases (e.g., Zellweger’s Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound. | | Uses | Tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE (HY-124404A) in numerous tissues. 12(S)‐HETE to tetranor‐12(S)‐HETE conversion could be a marker for psoriasis[1]. | | Definition | ChEBI: Tetranor 12-HETE is a hydroxy fatty acid. | | References | [1] Setkowicz M, et al. Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid. Br J Dermatol. 2015 Feb;172(2):337-44. DOI:10.1111/bjd.13225 |
| | TETRANOR-12(S)-HETE Preparation Products And Raw materials |
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