Tetranor-12(S)-hete manufacturers
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| | Tetranor-12(S)-hete Basic information |
| Product Name: | Tetranor-12(S)-hete | | Synonyms: | KBOVKDIBOBQLRS-ONCCEEIJSA-N;4,6,10-Hexadecatrienoic acid, 8-hydroxy-, [S-(E,Z,Z)]- (9CI);Tetranor-12(S)-hete | | CAS: | 121842-79-3 | | MF: | C16H26O3 | | MW: | 266.38 | | EINECS: | | | Product Categories: | | | Mol File: | 121842-79-3.mol |  |
| | Tetranor-12(S)-hete Chemical Properties |
| storage temp. | Store at -20°C | | solubility | 0.1 M Na2CO3: 2 mg/ml; DMF: 25 mg/ml; DMSO: 25 mg/ml; Ethanol: 30 mg/ml; PBS (pH 7.2): .5 mg/ml |
| | Tetranor-12(S)-hete Usage And Synthesis |
| Description | 12(S)-HETE is a product of arachidonic acid metabolism through the 12-lipoxygenase pathway. It is primarily found in platelets, leukocytes, and to a lesser extent in smooth muscle cells. It enhances tumor cell adhesion to endothelial cells, fibronectin, and the subendothelial matrix. tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE in numerous tissues, and Lewis lung carcinoma cells. No biological function has yet been determined for tetranor-12(S)-HETE. Some data indicate it may play a role in controlling the inflammatory response in injured corneas. In some diseases (e.g., Zellweger’s Syndrome) peroxisomal abnormalities result in the inability of cells to metabolize 12(S)-HETE, which may be responsible for symptoms of the disease. The tetranor derivative of 12(S)-HETE is available as a research tool for the elucidation of the metabolic fate of its parent compound. | | Uses | Tetranor-12(S)-HETE is the major β-oxidation product resulting from peroxisomal metabolism of 12(S)-HETE (HY-124404A) in numerous tissues. 12(S)‐HETE to tetranor‐12(S)‐HETE conversion could be a marker for psoriasis[1]. | | Definition | ChEBI: Tetranor 12-HETE is a hydroxy fatty acid. | | References | [1] Setkowicz M, et al. Lack of association of ALOX12 and ALOX15B polymorphisms with psoriasis despite altered urinary excretion of 12(S)-hydroxyeicosatetraenoic acid. Br J Dermatol. 2015 Feb;172(2):337-44. DOI:10.1111/bjd.13225 |
| | Tetranor-12(S)-hete Preparation Products And Raw materials |
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