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Physalaemin manufacturers
- PHYSALAEMIN
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- $1.00
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2020-03-06
- CAS:2507-24-6
- Min. Order: 1g
- Purity: ≥98%
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| | Physalaemin Basic information |
| Product Name: | Physalaemin | | Synonyms: | FI 6422;Physalemin(7CI,8CI,9CI);PGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PHYSALAEMIN;PHYSALAEMIN ACOH 3H2O;PYROGLU-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET NH2;PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2;PYR-ALA-ASP-PRO-ASN-LYS-PHE-TYR-GLY-LEU-MET-NH2 ACOH 3H2O | | CAS: | 2507-24-6 | | MF: | C58H84N14O16S | | MW: | 1265.44 | | EINECS: | | | Product Categories: | Peptide | | Mol File: | 2507-24-6.mol |  |
| | Physalaemin Chemical Properties |
| Boiling point | 1743.208±65.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.331±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | −20°C | | solubility | Soluble in DMSO | | pka | 4.306±0.19(predicted) | | Sequence | GLP-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2 | | InChIKey | SHSUJLMLURFKID-PYQGFWJGNA-N |
| | Physalaemin Usage And Synthesis |
| Description | Physalaemin is an oligopeptide that is originally derived from the skin of the South American frog Physalaemus fuscumaculatus. It belongs to the class of kinins and shares a similar chemical structure and mode of action with Substance P. It is a potent vasodilator and has hypotensive effects. | | Uses | Physalaemin is a neuropeptide found in amphibians that has shown potential in the treatment of Sjogren's disease. | | Biological Activity | Physalaemin is a non-mammalian tachykinin that selectively binds with high affinity to the neurokinin-1 (NK1) receptor. | | in vitro | Physalaemin (PHY), an undecapeptide with the sequence pGlu-Ala-Asp-Pro-Asn-Lys-Phe-Tyr-Gly-Leu-Met-NH2, is a member of the tachykinin family of neuropeptides. PHY is very close to the mammalian tachykinin substance P (SP) in its function and chemical composition, and SP is well studied and characterized. Physalaemin is a bradykinin potentiating peptide (BPP-5a). | | target | Neurokinin-1 (NK1) receptor | | References | [1] Grace CR, et al. Solution conformation of non-mammalian tachykinin physalaemin in lipid micelles by nuclear magnetic resonance. Biopolymers. 2011;96(3):252-9. DOI:10.1002/bip.21519
[2] Kobayashi J, Hydrolytic cleavage of pyroglutamyl-peptide bond. V. selective removal of pyroglutamic acid from biologically active pyroglutamylpeptides in high concentrations of aqueous methanesulfonic acid. Chem Pharm Bull (Tokyo). 2006 Jun;54(6):827-31. DOI:10.1248/CPB.54.827
[3] Hypotensive effect of eledoisin, physalaemin and related peptides in man DOI: 10.1007/BF00535905
[4] Physalaemin Inhibits Thyrotropin Secretion in Rats DOI: 10.1055/s-0029-1210457
[5] Action of Physalaemin on the Ionic Transport Across the Frog Skin: Archives of Physiology and Biochemistry: Vol 105, No DOI: 10.1055/s-0029-1210457 |
| | Physalaemin Preparation Products And Raw materials |
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