CP 154526 manufacturers
- CP 154,526
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- $2380.00
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2026-04-21
- CAS:157286-86-7
- Purity:
- Supply Ability: 10g
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| | CP 154526 Basic information |
| Product Name: | CP 154526 | | Synonyms: | N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine;7H-Pyrrolo[2,3-d]pyrimidin-4-amine,N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-;N-butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)pyrrolo[2,3-d]pyrimidin-4-amine;CP-154,526;N-Butyl-N-ethyl-2,5-dimethyl-7-(2,4,6-trimethylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-4-aminehydrochloride;CP 154;CP154;CP-154 | | CAS: | 157286-86-7 | | MF: | C23H32N4 | | MW: | 364.53 | | EINECS: | | | Product Categories: | Amines;Aromatics;Heterocycles;Intermediates & Fine Chemicals;Neurochemicals;Pfizer Compounds;Pharmaceuticals | | Mol File: | 157286-86-7.mol |  |
| | CP 154526 Chemical Properties |
| Boiling point | 423.5±45.0 °C(Predicted) | | density | 1.06 | | storage temp. | Desiccate at +4°C | | pka | 6.97±0.30(Predicted) |
| | CP 154526 Usage And Synthesis |
| Uses | A selective, non-peptide antagonist of corticotropin releasing factor receptors (CRF1). It blocks CRF-induced adenylate cyclase activation and attenuates activation of the HPA axis by CRF. It displayed anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant. | | Biological Activity | Selective, non-peptide CRF 1 receptor antagonist (K i values are 2.7 and > 10000 nM for CRF 1 and CRF 2 receptors respectively). Blocks CRF-induced adenylate cyclase activation (K i = 3.7 nM) and attenuates activation of the HPA axis by CRF. Displays anxiolytic-like activity in the rat elevated plus-maze test; brain penetrant. | | in vivo | CP 154526 (1-10 mg/kg; i.p.; once) exhibits signs of anxiolytic-like activity in the elevated plus-maze test in rats[2]. | Animal Model: | Male Sprague Dawley rats[2] | | Dosage: | 1 mg/kg, 3 mg/kg, 10 mg/kg | | Administration: | i.p.; once | | Result: | Exhibited signs of anxiolytic-like activity.
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| | CP 154526 Preparation Products And Raw materials |
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