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| | 1-Boc-6-amino-indazole Basic information |
| Product Name: | 1-Boc-6-amino-indazole | | Synonyms: | 6-AMINO-1H-INDAZOLE-1-CARBOXYLIC ACID, 1,1 DIMETHYL ETHYL ESTER;6-AMINO-1-N-TERT-BUTOXYCARBONYL-1H-INDAZOLE;6-AMINO-INDAZOLE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;tert-butyl 6-amino-1H-indazole-1-carboxylate;6-Amino-1H-indazole, N1-BOC protected;1H-Indazole-1-carboxylic acid, 6-aMino-, 1,1-diMethylethyl ester;6-Amino-1H-indazole, N1-BOC;tert-Butyl 6-amino-1H-indazole-1-carboxylate, 6-Amino-1-(tert-butoxycarbonyl)-1H-indazole | | CAS: | 219503-81-8 | | MF: | C12H15N3O2 | | MW: | 233.27 | | EINECS: | | | Product Categories: | Indazoles;Building Blocks;Indazole | | Mol File: | 219503-81-8.mol |  |
| | 1-Boc-6-amino-indazole Chemical Properties |
| Melting point | 171-172℃ | | Boiling point | 395.3±34.0 °C(Predicted) | | density | 1.24±0.1 g/cm3(Predicted) | | storage temp. | under inert gas (nitrogen or Argon) at 2–8 °C | | pka | 2.52±0.10(Predicted) | | form | powder | | color | Yellow | | Water Solubility | Slightlysoluble in water. |
| | 1-Boc-6-amino-indazole Usage And Synthesis |
| Uses | Used in the synthesis of chiral molecules. | | Synthesis | Step B: Preparation of tert-butyl 6-amino-1H-indazole-1-carboxylate: To a solution of tert-butyl 6-nitro-1H-indazole-1-carboxylate (0.88 g, 3.34 mmol) in methanol (20 mL) was added 10% Pd/C catalyst (0.355 g, 0.334 mmol). After displacing the air in the reaction system with nitrogen, the hydrogenation reaction was carried out under hydrogen (30 psi) atmosphere for 2 hours. After completion of the reaction, the reaction mixture was filtered through GF/F filter paper and the filtrate was concentrated to afford the target product tert-butyl 6-amino-1H-indazole-1-carboxylate (0.76 g, 98% yield). Mass spectrometry analysis (APCI-positive ion mode) showed [M+1]+ peak of 233.8. | | References | [1] Patent: US2010/63066, 2010, A1. Location in patent: Page/Page column 35
[2] Journal of Medicinal Chemistry, 2002, vol. 45, # 4, p. 944 - 954
[3] Patent: US6372759, 2002, B1
[4] Bioorganic and Medicinal Chemistry, 2013, vol. 21, # 13, p. 3821 - 3830
[5] Asian Journal of Chemistry, 2014, vol. 26, # 22, p. 7539 - 7543 |
| | 1-Boc-6-amino-indazole Preparation Products And Raw materials |
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