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GSK-3 β inhibitor 2 manufacturers
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| | GSK-3 β inhibitor 2 Basic information |
| Product Name: | GSK-3 β inhibitor 2 | | Synonyms: | GSK-3 β inhibitor 2;GSK-3β inhibitor 2;5-Thiazolecarboxamide,2-[2-[(cyclopropylcarbonyl)amino]-4-pyridinyl]-4-methoxy-;2-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxamide;2-(2-(Cyclopropanecarboxamido)pyridin-4-yl)-4-methoxythiazole-5-carboxamide?, GSK-3β inhibitor 2 | | CAS: | 1702428-31-6 | | MF: | C14H14N4O3S | | MW: | 318.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1702428-31-6.mol |  |
| | GSK-3 β inhibitor 2 Chemical Properties |
| density | 1.475±0.06 g/cm3(Predicted) | | solubility | DMSO: Sparingly soluble: 1-10 mg/ml | | form | Solid | | pka | 13.08±0.20(Predicted) | | color | Light yellow to yellow |
| | GSK-3 β inhibitor 2 Usage And Synthesis |
| Uses | GSK-3β inhibitor 2 (Compound 3) is a potent, selective and orally active GSK-3β inhibitor with an IC50 of 1.1 nM. GSK-3β inhibitor 2 can cross the blood-brain barrier. GSK-3β inhibitor 2 has the potential for Alzheimer's disease[1]. | | in vivo | The elevation of hyperphosphorylated Tau (pTau) is mimicked in LaFerla 3xTg-C57BL6 mice, and accordingly, these mice are used as an in vivo model of Alzheimer’s disease. GSK-3β inhibitor 2 (Compound 3) shows a significant reduction in pTau396 when administered orally at 30 mg/kg as a nanosuspension to LaFerla 3xTg-C57BL6 male mice. GSK-3β inhibitor 2 shows only modest brain exposure (B/P = 0.26) as determined as a single time point[1]. | | IC 50 | GSK-3β: 1.1 nM (IC50) | | References | [1] Sivaprakasam P, et al. Discovery of new acylaminopyridines as GSK-3 inhibitors by a structure guided in-depth exploration of chemical space around a pyrrolopyridinone core. Bioorg Med Chem Lett. 2015 May 1;25(9):1856-63. DOI:10.1016/j.bmcl.2015.03.046 |
| | GSK-3 β inhibitor 2 Preparation Products And Raw materials |
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