| Company Name: |
Alfa Chemistry |
| Tel: |
1-516-6625404 |
| Email: |
support@alfa-chemistry.com |
| Company Name: |
BOC Sciences |
| Tel: |
+1-631-485-4226 |
| Email: |
inquiry@bocsci.com |
|
| | 15-KEDE Basic information |
| Product Name: | 15-KEDE | | Synonyms: | QZCMHXPXGACWLJ-QWAPPMFBSA-N;15-KEDE;(11Z,13E)-15-oxoicosa-11,13-dienoic acid;11,13-Eicosadienoic acid, 15-oxo-, (11Z,13E)-;15-OXOEDE;15-OXO-11Z,13E-EICOSADIENOIC ACID | | CAS: | 105835-44-7 | | MF: | C20H34O3 | | MW: | 322.48 | | EINECS: | | | Product Categories: | | | Mol File: | 105835-44-7.mol |  |
| | 15-KEDE Chemical Properties |
| Boiling point | 477.8±18.0 °C(Predicted) | | density | 0.955±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMF: 50 mg/ml; DMSO: 50 mg/ml; Ethanol: 50 mg/ml; PBS pH 7.2: 1 mg/ml | | pka | 4.78±0.10(Predicted) |
| | 15-KEDE Usage And Synthesis |
| Description | 15-OxoEDE is produced by the oxidation of 15-HEDE. 15-OxoEDE inhibits 5-LO from RBL-1 cells with an IC50 of 55 μM, which is about 2-fold lower than 15(S)-HEDE. A related oxo-eicosanoid, 5-oxoETE, is biosynthesized from 5(S)-HETE by a specific dehydrogenase and has potent inflammatory activity. | | Uses | 15-OxoEDE is an ester product. | | Definition | ChEBI: 15-oxoEDE is an oxoeicosadienoic acid that consists of 11Z,13E-oxoeicosadienoic acid with the oxo substituent located at position 15. It has a role as a metabolite. It is an OxoEDE and an enone. It is functionally related to a 15-HEDE. It is a conjugate acid of a 15-oxo-EDE(1-). | | References | [1] F. HAVIV. ChemInform Abstract: Structural Requirements for the Inhibition of 5-Lipoxygenase by 15-Hydroxyeicosa-5,8,11,13-tetraenoic Acid Analogues.[J]. ChemInform, 1987, 18 28. DOI: 10.1002/chin.198728356 |
| | 15-KEDE Preparation Products And Raw materials |
|