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| | H-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 Basic information |
| Product Name: | H-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 | | Synonyms: | MALIGNANT MELANOMA METASTASIS-SUPPRESSOR KISS-1 (109-121) (HUMAN);METASTIN (42-54) (HUMAN);KISSPEPTIN-54 (42-54) (HUMAN);KISSPEPTIN-13;KISSPEPTIN-13 (HUMAN);KISSPEPTIN-14 (2-14) (HUMAN);KISS-1 (109-121) (HUMAN);LEU-PRO-ASN-TYR-ASN-TRP-ASN-SER-PHE-GLY-LEU-ARG-PHE-NH2 | | CAS: | 374675-18-0 | | MF: | C78H107N21O18 | | MW: | 1626.81 | | EINECS: | | | Product Categories: | | | Mol File: | 374675-18-0.mol |  |
| | H-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 Chemical Properties |
| Sequence | Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 |
| | H-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 Usage And Synthesis |
| Uses | Kisspeptin 13 inhibits glucose-induced insulin secretion with an IC50 of 1.2 nM. Kisspeptin 13 activates the hypothalamic-pituitary-adrenal (HPA) axis, causes hyperthermia, motor behavior and anxiety in rats. Kisspeptin 13 interacts with α2-adrenergic and 5-HT2 serotonin receptors, exhibits antidepressant efficacy. Kisspeptin 13 is an activator for GPR54 and GnRH receptor, which enhances memory and can be used in Alzheimer's disease research[1][2][3][4]. | | in vivo | Kisspeptin 13 (intracerebroventricular administration; 2 μg/side; once) treatment improves object recognition memory impairment induced by Aβ through activation of GPR54 and GnRH receptor[1]. | Animal Model: | Male Swiss mice with memory impairment induced by A-beta[1] | | Dosage: | 2 μg/side | | Administration: | Intracerebroventricular administration; 2 μg/side; once | | Result: | Facilitated memory formation and prolonged memory retention through activation of the GPR54 and GnRH receptors, and suppressed memory-impairing effect of Aβ through activation of the GPR54. |
| | References | [1] Jiang JH, et al. Kisspeptin-13 enhances memory and mitigates memory impairment induced by Aβ1-42 in mice novel object and object location recognition tasks. Neurobiol Learn Mem. 2015 Sep;123:187-95. DOI:10.1016/j.nlm.2015.05.010
[2] Silvestre RA, et al., Kisspeptin-13 inhibits insulin secretion without affecting glucagon or somatostatin release: study in the perfused rat pancreas. J Endocrinol. 2008 Feb;196(2):283-90. DOI:10.1677/JOE-07-0454
[3] Csabafi K, et al., Effects of kisspeptin-13 on the hypothalamic-pituitary-adrenal axis, thermoregulation, anxiety and locomotor activity in rats. Behav Brain Res. 2013 Mar 15;241:56-61. DOI:10.1016/j.bbr.2012.11.039
[4] Tanaka M, et al., Neurotransmissions of antidepressant-like effects of kisspeptin-13. Regul Pept. 2013 Jan 10;180:1-4. DOI:10.1016/j.regpep.2012.08.017 |
| | H-Leu-Pro-Asn-Tyr-Asn-Trp-Asn-Ser-Phe-Gly-Leu-Arg-Phe-NH2 Preparation Products And Raw materials |
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