| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Ppc-1
CAS:1245818-17-0
Package:1removed
|
| Company Name: |
Cayman Chemical Company
|
| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:Ppc-1
CAS:1245818-17-0
|
| Company Name: |
Cellosaurus STR
|
| Tel: |
13121892008 |
| Email: |
cellosaurus@sib.swiss |
| Products Intro: |
Product Name:PPC-1
|
Ppc-1 manufacturers
- Ppc-1
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- $1980.00
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2026-05-11
- CAS:1245818-17-0
- Purity:
- Supply Ability: 10g
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| Product Name: | Ppc-1 | | Synonyms: | Ppc-1;Ppc1,Ppc 1;2-Quinolinecarboxylic acid, 4-methoxy-8-[(3-methyl-2-buten-1-yl)oxy]-, 3-methyl-2-buten-1-yl ester | | CAS: | 1245818-17-0 | | MF: | C21H25NO4 | | MW: | 355.43 | | EINECS: | | | Product Categories: | | | Mol File: | 1245818-17-0.mol |  |
| | Ppc-1 Chemical Properties |
| Boiling point | 494.8±40.0 °C(Predicted) | | density | 1.105±0.06 g/cm3(Predicted) | | pka | 0+-.0.50(Predicted) |
| | Ppc-1 Usage And Synthesis |
| Description | Ppc-1 is an anti-obesity agent. It shows mitochondrial uncoupling activity in vitro and anti-obesity activity in vivo. Ppc-1 is also an inhibitor of interleukin-2 (IL2) production in Jurkat cells. | | Uses | Ppc-1 is a mitochondrial uncoupler. Ppc-1 enhances mitochondrial oxygen consumption without adverse effects on ATP production. Ppc-1 is a cell-permeate interleukin-2 (IL-2) inhibitor. Ppc-1 inhibits the Gram-negative periodontopathogen Porphyromonas gingivalis. Ppc-1 has anti-obesity, antibacterial and anti-inflammatory activities[1][2][3][4]. | | in vivo | Ppc-1 (0-10 mg /kg; Intraperitoneal injection; once a week; for 8 weeks; female ICR mice) treatment suppresses weight gain with no abnormal effects on liver or kidney tissues, and no evidence of tumor formation[1].
Serum fatty acid levels are significantly elevated in mice treated with Ppc-1, while body fat content remained low. After a single administration, Ppc-1 distributes into various tissues of individual animals at low levels. Ppc-1 stimulates adipocytes in culture to release fatty acids, which might explain the elevated serum fatty acids in Ppc-1-treated mice[1]. | Animal Model: | Female ICR mice[1] | | Dosage: | 0 mg /kg , 0.16 mg /kg, 0.8 mg /kg, 4 mg /kg, and 10 mg /kg | | Administration: | Intraperitoneal injection; once a week; for 8 weeks | | Result: | Suppresseed weight gain in animals.
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| | IC 50 | IL-2 | | References | [1] Suzuki T, et al. Weight loss by Ppc-1, a novel small molecule mitochondrial uncoupler derived from slime mold. PLoS One. 2015 Feb 10;10(2):e0117088. DOI:10.1371/journal.pone.0117088
[2] Ogura M, et al. Prenylated quinolinecarboxylic acid derivative suppresses immune response through inhibition of PAK2. Biochem Pharmacol. 2016 Apr 1;105:55-65. DOI:10.1016/j.bcp.2016.01.020
[3] Haruhisa Kikuchi a, et al. Novel prenylated and geranylated aromatic compounds isolated from Polysphondylium cellular slime molds. Tetrahedron 66 (2010) 6000-6007.
[4] Azelmat J, et al. Antibacterial and Anti-inflammatory Activities of Ppc-1, Active Principle of the Cellular Slime Mold Polysphondylium pseudo-candidum. Med Chem. 2015;11(7):666-9. DOI:10.2174/1573406411666150430121640 |
| | Ppc-1 Preparation Products And Raw materials |
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