POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE

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POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE Basic information
Product Name:POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE
Synonyms:POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE;polymyxinbnonapeptide;N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-);N2-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-Thr-);Nα-(L-Thr-L-A2bu-)Cyclo(L-A2bu*-L-A2bu-D-Phe-L-Leu-L-A2bu-L-A2bu-L-Thr-);sPMBN;2-10-Polymyxin B1;Thr-{Dab}-{Dab}-{Dab}-d-Phe-Leu-{Dab}-{Dab}-Thr (Lactam: Dab3-Thr9)
CAS:86408-36-8
MF:C43H74N14O11
MW:963.14
EINECS:
Product Categories:Other Peptides;Peptides and Proteins;Peptides for Cell Biology
Mol File:86408-36-8.mol
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE Structure
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE Chemical Properties
Boiling point 1456.2±65.0 °C(predicted)
density 1.32±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
storage temp. 2-8°C
solubility Water: ≥ 100 mg/mL (103.83 mM); DMSO: 16.67 mg/mL (17.31 mM)
form Solid
pka12.10±0.45(predicted)
color White to off-white
SequenceH-Thr-Dab-Dab-Dab-d-Phe-Leu-Dab-Dab-Thr-OH(Lactam: Dab3-Thr10)
Safety Information
WGK Germany 3
MSDS Information
ProviderLanguage
SigmaAldrich English
POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE Usage And Synthesis
UsesPolymyxin B Nonapeptide can be used in biological study of role of outer membrane and porins in susceptibility of β-lactamase-producing Enterobacteriaceae to ceftazidime-avibactam.
in vivo

Polymyxin B nonapeptide (1.5, 3.0 mg/kg intravenously for 29 days) does not exhibit neuromuscular blocking, neurotoxic, or nephrotoxic effects in rats as observed with polymyxin B sulfate[2].

POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE Preparation Products And Raw materials
Tag:POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE(86408-36-8) Related Product Information
5-Hydroxypyridine-2-carboxylic acid ethyl ester Polymyxin B nonapeptide TFA ethyl (S)-5-oxopiperidine-2-carboxylate Avibactam Impurity Trans-5-(Benzyloxyamino)piperidine-2-carboxylic acid Avibactam Impurity 1 Avibactam Sodium Isomer Avibactam Impurity 10 Benzyl (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxylate ethanedioate O-(Benzyloxymethyl)hydroxylamine L-Norleucine, 6-chloro-N-[(1,1-dimethylethoxy)carbonyl]-5-[(phenylmethoxy)imino]-, phenylmethyl ester (2S,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamide Avibactam Impurity 28 Avibactam INT 1 Avibactam Impurity Avibactam Impurity 15 (2S,5R)-5-[(benzyloxy)amino]piperidine-2-carboxamide POLYMYXIN B NONAPEPTIDE HYDROCHLORIDE