Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- manufacturers
- sulfopin
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- $30.00 / 1mg
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2025-12-05
- CAS:2451481-08-4
- Min. Order:
- Purity: 99.99%
- Supply Ability: 10g
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| | Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Basic information |
| Product Name: | Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- | | Synonyms: | Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)-;sulfopin;1-dioxido-3-thienyl)-;2-dimethylpropyl)-N-(tetrahydro-1;neuroblastoma,antiproliferative,PIN1-3,tumors,cancer,pancreatic,Inhibitor,sulfopin,inhibit,cells,HEK293;2-Chloro-N-(1,1-dioxidotetrahydrothiophen-3-yl)-N-neopentylacetamide;sulfopin, 10 mM in DMSO;PIN1-3 | | CAS: | 2451481-08-4 | | MF: | C11H20ClNO3S | | MW: | 281.8 | | EINECS: | | | Product Categories: | | | Mol File: | 2451481-08-4.mol |  |
| | Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Chemical Properties |
| Boiling point | 455.5±45.0 °C(Predicted) | | density | 1.23±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | solubility | Soluble in DMSO (>25 mg/ml) | | form | solid | | pka | -1.36±0.20(Predicted) | | color | Off-white | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month. | | InChI | InChI=1S/C11H20ClNO3S/c1-11(2,3)8-13(10(14)6-12)9-4-5-17(15,16)7-9/h9H,4-8H2,1-3H3 | | InChIKey | NMHVAHHYKGXBMY-UHFFFAOYSA-N | | SMILES | C(N(CC(C)(C)C)C1CCS(=O)(=O)C1)(=O)CCl |
| | Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Usage And Synthesis |
| Description | Sulfopin (2451481-08-4) is a potent and selective covalent inhibitor of peptidyl-prolyl isomerase NIMA interacting-1 (Pin1) (Ki = 17 nM).1 Although it displayed little to no cytotoxicity against a panel of 300 cancer cell lines, it had a significant impact on cancer cell growth after prolonged treatment. It suppressed MYCN-driven neuroblastoma initiation and the growth and survival of primary neuroblastoma tumor cell transplants in zebrafish. | | Uses | Sulfopin (PIN1-3) is a highly selective covalent inhibitor of Pin1 with an apparent Ki of 17 nM. Sulfopin blocks Myc-driven tumors in vivo. The peptidyl-prolyl isomerase, Pin1, is exploited in cancer to activate oncogenes and inactivate tumor suppressors[1]. | | in vivo | Sulfopin (40 mg/kg; p.o.; QD/BID for 7 days) regresses neuroblastoma in mice[1].
Sulfopin (20-40 mg/kg; i.p.; daily for 27 days) inhibits pancreatic cancer progression in mice[1].
Sulfopin (25-100 μM) blocks neuroblastoma in zebrafish[1]. | Animal Model: | Transgenic Th-MYCN mice[1] | | Dosage: | 40 mg/kg | | Administration: | Once a day (QD) or twice a day (BID) for 7 days | | Result: | Sulfopin-treated QD mice showed a significant average increase in survival of 10 days, while Sulfopin-treated BID mice showed an even more pronounced average increase of 28 days.
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| | References | [1] CHRISTIAN DUBIELLA. Sulfopin is a covalent inhibitor of Pin1 that blocks Myc-driven tumors in vivo[J]. Nature chemical biology, 2021, 17 9: 954-963. DOI:10.1038/s41589-021-00786-7 |
| | Acetamide, 2-chloro-N-(2,2-dimethylpropyl)-N-(tetrahydro-1,1-dioxido-3-thienyl)- Preparation Products And Raw materials |
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