N-Eicosanoyl Serotonin

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N-Eicosanoyl Serotonin Suppliers list
Company Name: Focus Biomolecules  
Tel: 855-362-8721
Email: sales@focusbiomolecules.com
N-Eicosanoyl Serotonin Basic information
Product Name:N-Eicosanoyl Serotonin
Synonyms:N-Eicosanoyl Serotonin
CAS:
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
N-Eicosanoyl Serotonin Structure
N-Eicosanoyl Serotonin Chemical Properties
storage temp. -20°
solubility Soluble in DMSO (up to 30 mg/ml) or in Ethanol (up to 20 mg/ml with warming)
form solid
color Beige
Stability:Stable for 2 years from date of purchase supplied. Protect from air. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
Safety Information
MSDS Information
N-Eicosanoyl Serotonin Usage And Synthesis
DescriptionN-Eicosanoyl serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy.1 It inhibits the PP2A methylesterase maintaining PP2A in a highly active state leading to hypophosphorylated α-synuclein. In mouse models it preserved neuronal integrity and function, diminished neuroinflammation and improved behavioral performance. It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease.2,3
UsesN-Eicosanoyl Serotonin is a natural product found in coffee which synergizes with caffeine in protecting the brain in models of α-synucleinopathy. It prevents Aβ-induced impairments in mouse models of Alzheimer’s disease
References[1] RUN YAN. Synergistic neuroprotection by coffee components eicosanoyl-5-hydroxytryptamide and caffeine in models of Parkinson’s disease and DLB.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2018: E12053-E12062. DOI:10.1073/pnas.1813365115
[2] KESAVA ASAM. Eicosanoyl-5-hydroxytryptamide (EHT) prevents Alzheimer’s disease-related cognitive and electrophysiological impairments in mice exposed to elevated concentrations of oligomeric beta-amyloid.[J]. PLoS ONE, 2017: e0189413. DOI:10.1371/journal.pone.0189413
[3] GUSTAVO BASURTO-ISLAS . Therapeutic benefits of a component of coffee in a rat model of Alzheimer’s disease[J]. Neurobiology of Aging, 2014, 35 12: Pages 2701-2712. DOI:10.1016/j.neurobiolaging.2014.06.012
N-Eicosanoyl Serotonin Preparation Products And Raw materials
Tag:N-Eicosanoyl Serotonin Related Product Information
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