1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-

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1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- manufacturers

  • T6167923
  • T6167923 pictures
  • $93.00
  • 2026-07-27
  • CAS:2437475-16-4
  • Purity: 99.28%
  • Supply Ability: 10g
  • T6167923
  • T6167923 pictures
  • $93.00
  • 2026-07-27
  • CAS:2437475-16-4
  • Purity: 99.28%
  • Supply Ability: 10g
1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Basic information
Product Name:1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-
Synonyms:1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-;T6167923,T-6167923;T6167923, 10 mM in DMSO;(S)-4-((3-Bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine-1-carboxamide;(S)-4-((3-Bromophenyl)sulfonyl)-N-(1-(thiophen-2-yl)ethyl)piperazine;TChemicalbook6167923,10mMinDMSO
CAS:2437475-16-4
MF:C17H20BrN3O3S2
MW:458.39
EINECS:
Product Categories:
Mol File:2437475-16-4.mol
1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Structure
1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Chemical Properties
density 1.530±0.06 g/cm3(Predicted)
pka12.87±0.20(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Usage And Synthesis
UsesT6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively[1][2].
in vivo

T6167923 (0.17 and 1 mg; i.p. once) survives the mice from intoxication with SEB and LPS injection[2].

Animal Model:16-20 week-old BALB/c mice with LPS potentiation model[2]
Dosage:0.17 and 1 mg
Administration:Intraperitoneal injection; 0.17 and 1 mg once
Result:Dose-dependently showed a therapeutic efficacy against SEB intoxication.
References[1] Saqib U, et al. Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy. SAR QSAR Environ Res. 2018 Apr;29(4):295-318. DOI:10.1080/1062936X.2018.1431308
[2] Olson MA, et al. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Sci Rep. 2015 Sep 18;5:14246. DOI:10.1038/srep14246
1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Preparation Products And Raw materials
Tag:1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]-(2437475-16-4) Related Product Information
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