| Company Name: |
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
|
| Tel: |
18818260767 |
| Email: |
sales@chemegen.com |
| Products Intro: |
Product Name:T6167923
CAS:2437475-16-4
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
|
| Company Name: |
Nantong Hi-Future Biotechnology Co., Ltd
|
| Tel: |
18051384581 |
| Email: |
sales@chemhifuture.com |
| Products Intro: |
Product Name:T6167923
CAS:2437475-16-4
Purity:98%HPLC Package:10mg，100mg，500mg，1g，2g，5g，10mg，More
|
1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- manufacturers
- T6167923
-
- $93.00 / 1mg
-
2026-04-22
- CAS:2437475-16-4
- Min. Order:
- Purity: 99.28%
- Supply Ability: 10g
- T6167923
-
- $93.00 / 1mg
-
2026-04-21
- CAS:2437475-16-4
- Min. Order:
- Purity: 99.28%
- Supply Ability: 10g
|
| | 1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Basic information |
| | 1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Chemical Properties |
| density | 1.530±0.06 g/cm3(Predicted) | | form | Solid | | pka | 12.87±0.20(Predicted) | | color | White to off-white |
| | 1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Usage And Synthesis |
| Uses | T6167923 is a selective inhibitor of MyD88-dependent signaling pathways. T6167923 directly binds to Toll/IL1 receptor (TIR) domain of MyD88 and disrupts MyD88 homodimeric formation. T6167923 inhibits NF-κB driven Staphylococcus enterotoxin AP (SEAP) activity, and improves anti-inflammatory activity with IC50s of 2.7 μM, 2.9 μM, 2.66 μM and 2.66 μM for IFN-γ, IL-1β, IL-6 and TNF-α, respectively[1][2]. | | in vivo | T6167923 (0.17 and 1 mg; i.p. once) survives the mice from intoxication with SEB and LPS injection[2]. | Animal Model: | 16-20 week-old BALB/c mice with LPS potentiation model[2] | | Dosage: | 0.17 and 1 mg | | Administration: | Intraperitoneal injection; 0.17 and 1 mg once | | Result: | Dose-dependently showed a therapeutic efficacy against SEB intoxication. |
| | References | [1] Saqib U, et al. Identifying the inhibition of TIR proteins involved in TLR signalling as an anti-inflammatory strategy. SAR QSAR Environ Res. 2018 Apr;29(4):295-318. DOI:10.1080/1062936X.2018.1431308
[2] Olson MA, et al. Discovery of small molecule inhibitors of MyD88-dependent signaling pathways using a computational screen. Sci Rep. 2015 Sep 18;5:14246. DOI:10.1038/srep14246 |
| | 1-Piperazinecarboxamide, 4-[(3-bromophenyl)sulfonyl]-N-[(1S)-1-(2-thienyl)ethyl]- Preparation Products And Raw materials |
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