Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]-

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Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]- Basic information
Product Name:Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]-
Synonyms:Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]-;Exatecan Intermediate 7;N-(3-Fluoro-7-(hydroxyimino)-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide;N-[(7E)-3-Fluoro-7-(hydroxyimino)-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthalenyl]acetamide;(Z)-N-(3-fluoro-7-(hydroxyimino)-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide
CAS:182182-32-7
MF:C13H13FN2O3
MW:264.25
EINECS:
Product Categories:
Mol File:182182-32-7.mol
Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]- Structure
Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]- Chemical Properties
Boiling point 536.4±50.0 °C(Predicted)
density 1.41±0.1 g/cm3(Predicted)
form Solid
pka8.93±0.20(Predicted)
color Light green to green
Safety Information
MSDS Information
Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]- Usage And Synthesis
UsesExatecan Intermediate 7 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 7 can be used to synthesize Antibody-Drug Conjugates (ADCs).
IC 50Camptothecins
References[1] Kamihara, et al. Aminotetralone derivatives and process for producing the same. World Intellectual Property Organization, WO9626181 A1 1996-08-29.
[2] Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. DOI:10.1111/j.1349-7006.1995.tb02468.x
Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]- Preparation Products And Raw materials
Tag:Acetamide, N-[3-fluoro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]-(182182-32-7) Related Product Information
N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide N,N'-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalene-1,7-diyl)diacetamide N-(8-Amino-6-fluoro-5-methyl-1-oxo-1,2,3,4-tetrahydronaphthalen-2-yl)acetamide Acetamide, N-(3-fluoro-5,6,7,8-tetrahydro-8-oxo-1-naphthalenyl)- Exatecan intermediate 11 Acetamide, N-[(7Z)-3-chloro-5,6,7,8-tetrahydro-7-(hydroxyimino)-4-methyl-8-oxo-1-naphthalenyl]-