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J & K SCIENTIFIC LTD.
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Product Name:AQ-RA 741
CAS:123548-16-3
Package:100Mg,10Mg,50Mg
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| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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18930552037 |
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Product Name:AQ-RA 741;11-[[4-[4-(DiethylaMino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one
CAS:123548-16-3
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Ascent Scientific
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4401179829988 |
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customerservice@ascentscientific.co.uk |
| Products Intro: |
Product Name:AQ-RA 741
CAS:123548-16-3
Purity:>99% Package:10mg;50mg Remarks:M2 antagonist
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| | 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Basic information |
| Product Name: | 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE | | Synonyms: | 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE;AQ-RA 741;11-(2-(4-(4-(Diethylamino)butyl)piperidin-1-yl)acetyl)-5H-benzo[e]pyrido[3,2-b][1,4]diazepin-6(11H)-one;11-[[4-[4-(Diethylamino)butyl]piperidin-1-yl]acetyl]-11H-pyrido[2,3-b][1,4]benzodiazepin-6(5H)-one;5,11-Dihydro-11-[[4-[4-(diethylamino)butyl]-1-piperidinyl]acetyl]-6H-pyrido[2,3-b][1,4]benzodiazepin-6-one;6H-Pyrido[2,3-b][1,4]benzodiazepin-6-one, 11-[2-[4-[4-(diethylamino)butyl]-1-piperidinyl]acetyl]-5,11-dihydro-;AQ-RA 741, M2 antagonist | | CAS: | 123548-16-3 | | MF: | C27H37N5O2 | | MW: | 463.61 | | EINECS: | | | Product Categories: | Acetylcholine receptor;Muscarinic | | Mol File: | 123548-16-3.mol | ![11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Structure](CAS/GIF/123548-16-3.gif) |
| | 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Chemical Properties |
| Boiling point | 602.7±50.0 °C(Predicted) | | density | 1.132±0.06 g/cm3(Predicted) | | storage temp. | Store at RT | | solubility | <46.36mg/ml in 1eq. HCl; <46.36mg/ml in ethanol; <46.36mg/ml in DMSO | | form | solid | | pka | 11.29±0.20(Predicted) | | color | White |
| | 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Usage And Synthesis |
| Uses | AQ-RA 741 acts as a potent and highly specific muscarinic M2 receptor antagonist, with potential application towards the development of bronchodilator anti-muscarinic agents for humans. | | Definition | ChEBI: 11-[2-[4-[4-(diethylamino)butyl]-1-piperidinyl]-1-oxoethyl]-5H-pyrido[2,3-b][1,4]benzodiazepin-6-one is a benzodiazepine. | | Biological Activity | High affinity, selective muscarinic M 2 receptor antagonist (pK i values are 8.3, 7.7 and 6.82 for M 2 , M 1 and M 3 receptors, respectively). In vivo, displays cardioselectivity over intestinal, tracheal and bladder muscarinic receptors; inhibits vagally and agonist-induced bradycardia. | | storage | Store at RT | | references | [1]. doods h, entzeroth m and mayer n. cardioselectivity of aq-ra 741, a novel tricyclic antimuscarinic drug. eur j pharmacol, 1991, 192(1):147-52.
[2]. gomeza j, shannon h, kostenis e, et al. pronounced pharmacologic deficits in m2 muscarinic acetylcholine receptor knockout mice. proc natl acad sci u s a, 1999, 96(4):1692-7. |
| | 11-[[4-[4-(DIETHYLAMINO)BUTYL]-1-PIPERIDINYL]ACETYL]-5,11-DIHYDRO-6H-PYRIDO[2,3-B][1,4]BENZODIAZEPIN-6-ONE Preparation Products And Raw materials |
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