Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt)

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Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt) Basic information
Product Name:Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt)
Synonyms:Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt)
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MW:0
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Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt) Structure
Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt) Chemical Properties
solubility DMSO: slightly solublePBS (pH 7.2): 10 mg/ml
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MSDS Information
Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt) Usage And Synthesis
DescriptionKallidin (380-389) is a short-lived kinin peptide involved in inflammation and pain.1 It binds to bradykinin B2 (IC50 = 0.63 nM) and B1 receptors (Ki = 3.23 nM) and acts as an agonist.1,2,3 It is formed in tissue, including the brain, via cleavage of low molecular weight kininogen (LMWK) by kallikrein serine proteases released in response to injury or inflammation and can be converted into bradykinin.1 Kallidin levels in interstitial muscle are increased in women with work-related trapezius myalgia.4WARNING This product is not for human or veterinary use.
References[1] DRAY A. Kinins and their receptors in hyperalgesia.[J]. Canadian journal of physiology and pharmacology, 1997, 75 6 1: 704-712. DOI: 10.1139/y97-068
[2] S. BASTIAN. Stable expression of human kinin B1 receptor in 293 cells: pharmacological and functional characterization[J]. British Journal of Pharmacology, 2009, 122 2: 393-399. DOI: 10.1038/sj.bjp.0701380
[3] J F HESS. Differential pharmacology of cloned human and mouse B2 bradykinin receptors.[J]. Molecular Pharmacology, 1994, 45 1: 1-8.
[4] BJÖRN GERDLE . Bradykinin and kallidin levels in the trapezius muscle in patients with work-related trapezius myalgia, in patients with whiplash associated pain, and in healthy controls – A microdialysis study of women[J]. PAIN®, 2008, 139 3: Pages 578-587. DOI: 10.1016/j.pain.2008.06.012
Kallidin (380-389) (human, porcine, bovine) (trifluoroacetate salt) Preparation Products And Raw materials
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