Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]-

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Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]- Basic information
Product Name:Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]-
Synonyms:Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]-;AGN 192870;4-((5,5-Dimethyl-8-phenyl-5,6-dihydronaphthalen-2-yl)ethynyl)benzoic acid
CAS:166977-57-7
MF:C27H22O2
MW:378.46
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Mol File:166977-57-7.mol
Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]- Structure
Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]- Chemical Properties
Boiling point 553.6±50.0 °C(Predicted)
density 1.23±0.1 g/cm3(Predicted)
pka4.08±0.10(Predicted)
form Solid
color Off-white to light yellow
Safety Information
MSDS Information
Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]- Usage And Synthesis
UsesAGN 192870 is a RAR neutral antagonist with Kds of 147, 33, and 42 nM for RARα, RARβ, and RARγ, respectively. AGN 192870 shows IC50s of 87 and 32 nM for RARαand RARγ, respectively. AGN 192870 shows RARβ partial agonism[1]. AGN 192870 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
References[1] Klein ES, et al. Identification and functional separation of retinoic acid receptor neutral antagonists and inverse agonists. J Biol Chem. 1996;271(37):22692-22696. DOI:10.1074/jbc.271.37.22692
Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]- Preparation Products And Raw materials
Tag:Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]-(166977-57-7) Related Product Information
(4,4',4'',4'''-((ethene-1,1,2,2-tetrayltetrakis(benzene-4,1-diyl))tetrakis(ethyne-2,1-diyl))tetrabenzoic acid) AGN 193109 Ethyl Ester 4-[(1E)-2-[5,6-Dihydro-5,5-dimethyl-8-(2-phenylethynyl)-2-naphthalenyl]ethenyl]benzoicacid BMS453 Benzoic acid, 4-[2-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)ethynyl]- 4-{[5,5-dimethyl-8-(4-methylphenyl)-5,6-dihydronaphthalen-2-yl]ethynyl}benzoic acid