4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate

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4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate manufacturers
4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Basic information
Product Name:4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate
Synonyms:4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate;PENTAMIDINE DIMETHANESULFONATE;Lomidine;Pentamidine dimesylate;pentamidine mesylate
CAS:6823-79-6
MF:C21H32N4O8S2
MW:532.63078
EINECS:229-898-4
Product Categories:
Mol File:6823-79-6.mol
4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Structure
4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Chemical Properties
Safety Information
RIDADR 3249
HazardClass 6.1(b)
PackingGroup III
MSDS Information
4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Usage And Synthesis
UsesPentamidine (MP-601205) dimesylate is an antimicrobial agent and interferes with DNA biosynthetics. Pentamidine dimesylate inhibits parasite Leishmania infantum with an IC50 of 2.5 μM. Pentamidine dimesylate is a potent and selective protein tyrosine phosphatases (PTPases) and phosphatase of regenerating liver (PRL) inhibitor. Pentamidine dimesylate has the potential for Gambian trypanosomiasis, antimony-resistant leishmaniasis, and Pneumocystis carinii pneumonia treatment. Antitumor and antibacterial activities[1][2][3][4].
in vivo

Pentamidine (0.25 mg/mouse; intramuscular injection; every 2 days; for 4 weeks; athymic nude mice) dimesylate treatment markedly inhibits the growth of WM9 human melanoma tumors in nude mice[1].

Animal Model:Athymic nude mice (6 weeks old) injected with WM9 cells[1]
Dosage:0.25 mg/mouse
Administration:Intramuscular injection; every 2 days; for 4 weeks
Result:Markedly inhibited the growth of WM9 human melanoma tumors in nude mice.
IC 50Trypanosoma; Leishmania
References[1] Pathak MK, et al. Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. Mol Cancer Ther. 2002 Dec;1(14):1255-64. PMID:12516958
[2] Nguewa, P.A., et al., Pentamidine is an antiparasitic and apoptotic drug that selectively modifies ubiquitin. Chem Biodivers, 2005. 2(10): p. 1387-400. DOI:10.1002/cbdv.200590111
[3] Sands M, et al. Pentamidine: a review. Rev Infect Dis. 1985 Sep-Oct;7(5):625-34. DOI:10.1093/clinids/7.5.625
[4] David C. Bean, et al. Pentamidine: a drug to consider re-purposing in the targeted treatment of multi-drug resistant bacterial infections J Lab Precis Med 2017;2:49.
4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Preparation Products And Raw materials
Tag:4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate(6823-79-6) Related Product Information
4,4'-[1,5-pentanediylbis(oxy)]bisbenzenecarboxamidine dimethylsulphonate Pentamidine isethionate Pentamidine ACP5 Protein, Mouse (HEK293, His) Acpp/prostatic acid phosphatase protein, mouse (HEK293, his) PTPRC/CD45R0 Protein, Human (Biotinylated, HEK293, His-Avi)