1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer

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1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer Suppliers list
Company Name: TargetMol Chemicals Inc.  
Tel: +1-781-999-5354; +1-00000000000
Email: marketing@targetmol.com
Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
Email: marketing@targetmol.cn
Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
Email: marketing@targetmol.com

1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer manufacturers

  • SMBA2
  • SMBA2 pictures
  • $1520.00
  • 2026-05-11
  • CAS:18304-79-5
  • Purity:
  • Supply Ability: 10g
1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer Basic information
Product Name:1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer
Synonyms:1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer;1,3,6,8-Tetraazatricyclo[6.2.1.13,6]dodecane;Einecs 242-188-9;SMBA 2;SMBA2;SMBA-2
CAS:18304-79-5
MF:C8H16N4
MW:168.24
EINECS:242-188-9
Product Categories:
Mol File:18304-79-5.mol
1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer Structure
1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer Chemical Properties
Melting point 180-196 °C
Boiling point 248.4±8.0 °C(Predicted)
density 1.28±0.1 g/cm3(Predicted)
pka6.27±0.20(Predicted)
Safety Information
MSDS Information
1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer Usage And Synthesis
UsesBax agonist 1 (compound SMBA2) is a Bax agonist (Ki=57.2 nM). Bax agonist 1 induces Bax conformational changes by blocking S184 phosphorylation, promoting Bax insertion into the mitochondrial membrane and forming Bax oligomers, which induce cytochrome c release and apoptosis in malignant cancer cells expressing Bax. Bax agonist 1 can be used in lung cancer research[1].
DefinitionChEBI: 1,3,6,8-tetraazatricyclo[6.2.1.1(3,6)]dodecane is an azatricycloalkane that is tricyclo[6.2.1.1(3,6)]dodecane in which the four bridgehead CH groups are replaced by nitrogen atoms. It is a small-molecule BAX agonist. It has a role as an apoptosis inducer and an antineoplastic agent. It is a bridged compound, a tetramine and an azatricycloalkane.
IC 50Bax: 57.2 nM (Ki)
References[1] Meiguo Xin, et al. Small-molecule Bax agonists for cancer therapy. Nature communications 5.1 (2014): 4935. DOI:10.1038/ncomms5935
1,3,6,8-tetraazatricyclo[6.2.1.13,6]dodecane, stereoisomer Preparation Products And Raw materials
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