ChemicalBook > Product Catalog >Biochemical Engineering >Inhibitors >Cytoskeletal Signaling >Kinesin Inhibitors >9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Basic information
Product Name:9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Synonyms:AZ 3146; AZ-3146;CS-511;9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one;AZ 3146;9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one;9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one;9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one AZ3146;9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9
CAS:1124329-14-1
MF:C24H32N6O3
MW:452.55
EINECS:
Product Categories:Inhibitors
Mol File:1124329-14-1.mol
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Structure
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Chemical Properties
Boiling point 621.0±65.0 °C(Predicted)
density 1.279
storage temp. Store at +4°C
solubility Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
pka8.29±0.10(Predicted)
form solid
color Off-white
Stability:Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKeyYUKWVHPTFRQHMF-UHFFFAOYSA-N
SMILESCN1CCC(OC2=CC(OC)=C(NC3=NC=C4C(N(C5CCCC5)C(N4C)=O)=N3)C=C2)CC1
Safety Information
WGK Germany WGK 3
Storage Class11 - Combustible Solids
MSDS Information
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Usage And Synthesis
DescriptionAZ3146 (1124329-14-1) is a potent (IC50= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2
UsesAZ 3146 is a protein kinase Mps1 inhibitor.
IC 50Mps1Cat: 35 nM (IC50)
storageStore at +4°C
References[1] LAURA HEWITT. Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex.[J]. Journal of Cell Biology, 2010, 190 1: 25-34. DOI:10.1083/jcb.201002133
[2] XING LIU. TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells.[J]. Oncotarget, 2015: 34309-34320. DOI:10.18632/oncotarget.5295
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Preparation Products And Raw materials
Tag:9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one(1124329-14-1) Related Product Information
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