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| | Xanthine amine congener dihydrochloride Basic information |
| | Xanthine amine congener dihydrochloride Chemical Properties |
| solubility | Soluble to 100 mM in DMSO |
| | Xanthine amine congener dihydrochloride Usage And Synthesis |
| Uses | Xanthine amine congener dihydrochloride (XAC dihydrochloride) is a potent Adenosine A1 receptor and A2receptor antagonist with IC50 values of 1.8 and 114 nM, respectively. Xanthine amine congener acts as a convulsant agent in mice model[1]. | | Biological Activity | XAC is an adenosine receptor antagonist (IC50 values are 1.8 and 114 nM at A1 and A2 receptors respectively). Attenuates adenosine-induced vasodilation and exhibits proconvulsant activity in vivo. | | in vivo | Xanthine amine congener dihydrochloride is more potent as a convulsant than either caffeine or theophyllin in infusion studies at the dosage 39.8 mg/kg. XAC has no effects by administering the drug via an i.p. injection, the seizure threshold >1000 mg/kg[1]. | Animal Model: | Mice[1] | | Dosage: | 39.8 mg/kg | | Administration: | Infusion injection; single dose | | Result: | Acted as a convulsant agent than either caffeine or theophyllin. |
| | storage | Desiccate at RT | | References | [1] P F Morgan, et al.Potent Convulsant Actions of the Adenosine Receptor Antagonist, Xanthine Amine Congener (XAC). Life Sci. 1989;45(8):719-28 DOI:10.1016/0024-3205(89)90091-x |
| | Xanthine amine congener dihydrochloride Preparation Products And Raw materials |
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