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(R)-(+)-9-(2-Hydroxypropyl)adenine

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Company Name: Shanghai Yingrui Biopharma Co.,Ltd
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Products Intro: Product Name:(R)-(+)-9-(2-Hydroxypropyl)adenine
CAS:14047-28-0
Purity:0.98 Package:25 kilograms per barrel
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Products Intro: Product Name:(R)-(+)-9-(2-Hydroxypropyl)Adenine
CAS:14047-28-0
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Products Intro: Product Name:(R) - (+) -9- (2-Hydroxypropyl) Adenine
CAS:14047-28-0
Purity:99% Package:1KG;10.70;USD
Company Name: ShenZhen H&D Pharmaceutical Technology Co., LTD
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Products Intro: Product Name:Tenofovir impurity 62
CAS:14047-28-0
Purity:0.98 Package:10mg
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:(R)-9-(2-hydroxypropyl)adenine
CAS:14047-28-0
Purity:98% (Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg

(R)-(+)-9-(2-Hydroxypropyl)adenine manufacturers

  • Tenofovir impurity 62
  • Tenofovir impurity 62 pictures
  • $0.00 / 10mg
  • 2026-03-02
  • CAS:14047-28-0
  • Min. Order: 10mg
  • Purity: 0.98
  • Supply Ability: 5g
(R)-(+)-9-(2-Hydroxypropyl)adenine Basic information
Product Name:(R)-(+)-9-(2-Hydroxypropyl)adenine
Synonyms:R-9-(2-hydroxypropyl) adenine, 9-HPA;(R)-(+)-9-(2-HYDROXYPROPYL)ADENINE,98%;(R)-(+)-9-(2-Hydroxypropyl)adenine;6-Amino-alpha-methyl-9H-purine-9-ethanol;Tenofovir (R)-Propanol Impurity;D-(-)-9-(2-Hydroxypropyl)adenine;(R)-9-[2-(Hydroxypropyl] Adenine (Desphosphoryl Tenofovir);(R)-6-aMino-alpha-Methyl-9H-purine-9-ethanol
CAS:14047-28-0
MF:C8H11N5O
MW:193.21
EINECS:604-188-0
Product Categories:Tenofovir;Chiral Reagents;Bases & Related Reagents;Nucleotides
Mol File:14047-28-0.mol
(R)-(+)-9-(2-Hydroxypropyl)adenine Structure
(R)-(+)-9-(2-Hydroxypropyl)adenine Chemical Properties
Melting point 193 °C
Boiling point 457.7±55.0 °C(Predicted)
density 1.57
storage temp. Keep in dark place,Inert atmosphere,2-8°C
solubility DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly, Heated)
form Solid
pka14.42±0.20(Predicted)
color White to Off-White
InChIInChI=1/C8H11N5O/c1-5(14)2-13-4-12-6-7(9)10-3-11-8(6)13/h3-5,14H,2H2,1H3,(H2,9,10,11)/t5-/s3
InChIKeyMJZYTEBKXLVLMY-GQMHJJTINA-N
SMILESN1(C[C@@H](C)O)C=NC2C(=NC=NC1=2)N |&1:2,r|
Safety Information
HS Code 2933.99.8290
MSDS Information
(R)-(+)-9-(2-Hydroxypropyl)adenine Usage And Synthesis
Chemical Propertieswhite powde
Uses(R)-9-[2-(Hydroxypropyl] Adenine (Desphosphoryl Tenofovir) (cas# 14047-28-0) is a useful reagent for preparing the antiviral drug tenofovir.
Synthesis
6H-Purin-6-imine, 1,7-dihydro- (9CI)

66224-66-6

(R)-(+)-Propylene carbonate

16606-55-6

(R)-(+)-9-(2-Hydroxypropyl)adenine

14047-28-0

To a reaction flask was added 200 mL of N,N-dimethylformamide (DMF) protected by N2, adenine (30.0 g, 0.222 mol, 1 equiv) and stirred. NaOH (0.45 g, 0.011 mol) and R-propylene carbonate (28.5 g, 0.279 mol, 1.26 eq.) were subsequently added. The reaction mixture was warmed to 130-140 °C within 12 h of the sampling test, and the reaction was stopped when the adenine content dropped to 1% or less. Slowly cooled to below 90°C, 200 mL of toluene was added, cooling was continued to 0-5°C, and the mixture was stirred for 2 hours. Filtered and dried to give 38.13 g white solid in 87% yield.

References[1] Patent: CN103848869, 2016, B. Location in patent: Paragraph 0053; 0054
[2] Patent: CN103848868, 2017, B. Location in patent: Paragraph 0055; 0058; 0059
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 26, p. 7799 - 7806
[4] Patent: WO2008/56264, 2008, A2. Location in patent: Page/Page column 69-70; 75; 81
[5] Patent: WO2015/51874, 2015, A1. Location in patent: Page/Page column 6; 20; 21
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