4-(N-Methyl-N-benzylamino)piperidine manufacturers
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| | 4-(N-Methyl-N-benzylamino)piperidine Basic information | | Application |
| Product Name: | 4-(N-Methyl-N-benzylamino)piperidine | | Synonyms: | 4-(N-METHYL-N-BENZYL)AMINOPIPERIDINE 2HCL;4-(N-Methyl-N-benzylamino)piperidine;N-Methyl-N-(phenylmethyl)-4-piperidinamine;N-benzyl-N-methylpiperidin-4-amine(SALTDATA: 2HCl);N-benzyl-N-methylpiperidin-4-amine 2HCl;N-Methyl-N-benzyl-4-piperidinaMine 2HCl;N-Benzyl-N-methylpiperidin-4-amine;N-(2-phenylethyl)-4-piperidinamine | | CAS: | 76167-62-9 | | MF: | C13H20N2 | | MW: | 204.31 | | EINECS: | 1312995-182-4 | | Product Categories: | | | Mol File: | 76167-62-9.mol |  |
| | 4-(N-Methyl-N-benzylamino)piperidine Chemical Properties |
| Boiling point | 118-120 °C(Press: 0.1 Torr) | | density | 1.01±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | pka | 10.11±0.10(Predicted) |
| RIDADR | UN2735 | | HazardClass | IRRITANT |
| | 4-(N-Methyl-N-benzylamino)piperidine Usage And Synthesis |
| Application | 4-(N-methyl-N-benzyl)aminopiperidine can be used as a pharmaceutical synthesis intermediate. If 4-bromoquinoline-6-carboxylic acid is inhaled, move the patient to fresh air. | | Synthesis | 4-(N-methyl-N-benzyl)aminopiperidine was prepared as follows: to a mixed solution of 1,4-dioxane/methanol (1/1, 8.0 mL) of 4-(N-benzyl-N-methylamino)piperidine-1-carboxylic acid tert-butyl ester (1.00 g, 3.28 mmol) was added to a 1,4-dioxane solution of hydrogen chloride (4.0 N, 3.28 mL.) at room temperature, 13.1 mmol) and the reaction solution was stirred at the same temperature for 6 hours. The reaction solution was concentrated under reduced pressure, saturated aqueous sodium bicarbonate solution was added and extracted with chloroform. The organic layer was dried with anhydrous sodium sulfate, filtered and the filtrate was concentrated under reduced pressure. The residue was purified by fast chromatography (silica gel, chloroform/methanol) to afford 4-(N-methyl-N-benzyl)aminopiperidine (0.650 g, 0.318 mmol, 97%) as a colorless oil.
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| | 4-(N-Methyl-N-benzylamino)piperidine Preparation Products And Raw materials |
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