|
|
| | 2-Amino-6-bromobenzoic acid Basic information |
| Product Name: | 2-Amino-6-bromobenzoic acid | | Synonyms: | 2-Amino-6-bromobenzoic acid;BP11632-amino-6-bromobenzoicacid;2-Amino-6-bromobenzoic acid 97%;3-Bromo-2-carboxyaniline, 6-Bromoanthranilic acid;6-BroMoanthranilic Acid;2-Nitro-5-broMobenzoic acid;2-AMino-6-broMobenzoic;2-AMINO-6-BROMOBENZOIC ACID(RS20012390) | | CAS: | 20776-48-1 | | MF: | C7H6BrNO2 | | MW: | 216.03 | | EINECS: | 630-293-6 | | Product Categories: | benzene derivative | | Mol File: | 20776-48-1.mol |  |
| | 2-Amino-6-bromobenzoic acid Chemical Properties |
| Melting point | 136 °C | | Boiling point | 348.9±32.0 °C(Predicted) | | density | 1.793±0.06 g/cm3(Predicted) | | storage temp. | Keep in dark place,Sealed in dry,Room Temperature | | form | powder | | pka | 0.85±0.10(Predicted) | | color | Light brown to beige | | Sensitive | Light Sensitive | | InChI | InChI=1S/C7H6BrNO2/c8-4-2-1-3-5(9)6(4)7(10)11/h1-3H,9H2,(H,10,11) | | InChIKey | BNQPROAXWQCNKO-UHFFFAOYSA-N | | SMILES | C(O)(=O)C1=C(Br)C=CC=C1N |
| Hazard Codes | Xi | | HazardClass | IRRITANT | | HS Code | 2916399090 |
| | 2-Amino-6-bromobenzoic acid Usage And Synthesis |
| Synthesis | General procedure for the synthesis of 2-amino-6-bromobenzoic acid from 4-bromoindoline-2,3-dione: Commercially available 4-bromoindigo (2.50 g, 11.1 mmol) was dissolved in 1.5 mol/L aqueous sodium hydroxide solution (20 mL), and 33% aqueous hydrogen peroxide solution (1 mL) was added slowly and dropwise at 55 °C. The reaction mixture was stirred continuously at 55 °C for 30 min and then cooled to room temperature. Subsequently, the reaction solution was neutralized with 2.0 mol/L hydrochloric acid solution and finally purified by HP-20 resin column to obtain the target product 2-amino-6-bromobenzoic acid (1.60 g, 67% yield). | | References | [1] Patent: EP2708540, 2014, A1. Location in patent: Paragraph 0092
[2] Proceedings of the Royal Society of London, Series B: Biological Sciences, 1958, vol. 148, p. 481,488
[3] Patent: WO2011/28741, 2011, A1. Location in patent: Page/Page column 202
[4] ACS Medicinal Chemistry Letters, 2016, vol. 7, # 9, p. 831 - 834 |
| | 2-Amino-6-bromobenzoic acid Preparation Products And Raw materials |
|