| Company Name: |
NCE Biomedical Co.,Ltd. |
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4000-027-021 |24 +86-13986109188 | +86-15623472865 | +81-08033611988 |
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- GW3965 HCl
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2025-04-04
- CAS:405911-17-3
- Min. Order: 1kg
- Purity: 98%
- Supply Ability: 1Ton
- GW 3965 HYDROCHLORIDE
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- $1.00
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2020-01-09
- CAS:405911-17-3
- Min. Order: 1KG
- Purity: 85.0-99.8%
- Supply Ability: 20tons
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| | GW 3965 hydrochloride Basic information |
| Product Name: | GW 3965 hydrochloride | | Synonyms: | 3-[3-[n-(2-chloro-3-trifluoromethylbenzyl)-(2,2-diphenylethyl)amino]propyloxy]phenylacetic acid hydrochloride;3-[3-[n-(2-chloro-3-trifluoroMethylbenzyl)-(2,2-di…;GW3965 HCl;2-[3-[3-[[2-Chloro-3-(trifluoromethyl)benzyl](2,2-diphenylethyl)amino]propoxy]phenyl]acetic acid hydrochloride;GW3965 hydrochloride, >=98%;Benzeneacetic acid, 3-[3-[[[2-chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]-, hydrochloride;GW3965 HCl Salt;3-[3-[[[2-Chloro-3-(trifluoromethyl)phenyl]methyl](2,2-diphenylethyl)amino]propoxy]benzeneacetic acid hydrochloride | | CAS: | 405911-17-3 | | MF: | C33H31ClF3NO3.HCl | | MW: | 0 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 405911-17-3.mol |  |
| | GW 3965 hydrochloride Chemical Properties |
| storage temp. | Store at -20°C | | solubility | DMSO: ≥20mg/mL | | form | powder | | color | white | | InChIKey | NMPUWJFHNOUNQU-UHFFFAOYSA-N | | SMILES | Cl[H].OC(=O)Cc1cccc(OCCCN(CC(c2ccccc2)c3ccccc3)Cc4cccc(c4Cl)C(F)(F)F)c1 |
| Hazard Codes | Xn | | Risk Statements | 22-41 | | Safety Statements | 26-39 | | WGK Germany | 3 | | Storage Class | 11 - Combustible Solids | | Hazard Classifications | Acute Tox. 4 Oral
Aquatic Chronic 4
Eye Dam. 1 |
| | GW 3965 hydrochloride Usage And Synthesis |
| Uses | GW3965 Hydrochloride, is a potent, selective liver X receptor (LXR) agonist for hLXRα and hLXR. GW3965 has shown potent anti-inflammatory activity in both irritant and allergic contact models of dermatitis, requiring the participation of both LXRα and LXRβ. | | Biochem/physiol Actions | GW3965 is a liver X receptor full agonist on hLXRα and hLXRβ. GW3965 has an EC50 = 125 nM in a cell-free ligand-sensing assay of LXRα and profiles as a full agonist on hLXRα and hLXRβ in cell-based assays with EC50 = 190 nM and 30 nM, respectively. It is orally active in mice. When screened against a panel of nuclear receptors, it cross-reacted with only the pregnane X receptor (PXR). The literature agonist, T0901317 (Tularik), had an EC50 = 60 nM and 85 nM in the cell-free and cell-based assays, respectively. | | in vivo | GW3965 hydrochloride induces an increase of neuroactive steroids in the spinal cord, the cerebellum and the cerebral cortex of STZ-rats, but not in the CNS of non-pathological animals. GW3965 hydrochloride treatment induces an increase of dihydroprogesterone in the spinal cord of diabetic animals in association with an increase of myelin basic protein expression[1]. GW3965 hydrochloride (40 mg/kg, p.o.) strongly induces ABCA1 expression and reduces LDLR expression, and this is accompanied by 59% inhibition of tumor growth, and a 25-fold increase in GBM cell apoptosis in vivo[2]. GW3965 hydrochloride (2 mg/kg, i.v.) increases bleeding time and modulated platelet thrombus formation in vivo[3]. | | storage | Desiccate at RT |
| | GW 3965 hydrochloride Preparation Products And Raw materials |
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