1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-

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1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy- Suppliers list
Company Name: Shanghai Haohong Pharmaceutical Co., Ltd.  
Tel: 400-8210725 4008210725
Email: malulu@leyan.com
Company Name: Henan Mengtai Pharmaceutical Technology Co., Ltd  
Tel: 17634413542
Email: 1959525201@qq.com
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy- Basic information
Product Name:1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-
Synonyms:1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-;4-amino-2-(2,6-dioxopiperidin-3-yl)-6-hydroxyisoindoline-1,3-dione;Pomalidomide-6-OH;4-Amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-1H-isoindole-1,3(2H)-dione
CAS:1547162-44-6
MF:C13H11N3O5
MW:289.24
EINECS:
Product Categories:
Mol File:1547162-44-6.mol
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy- Structure
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy- Chemical Properties
Boiling point 674.7±55.0 °C(Predicted)
density 1.677±0.06 g/cm3(Predicted)
pka7.13±0.20(Predicted)
form Solid
color Light yellow to yellow
Safety Information
MSDS Information
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy- Usage And Synthesis
UsesPomalidomide-6-OH is the Pomalidomide-based cereblon (CRBN) ligand used in the recruitment of CRBN protein. Pomalidomide-6-OH can be connected to the ligand for protein by a linker to form PROTAC[1].
IC 50Cereblon
References[1] Andrew J. Phillips, et al. Bromodomain targeting degronimers for target protein degradation. WO2017197056A1.
1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy- Preparation Products And Raw materials
Tag:1H-Isoindole-1,3(2H)-dione, 4-amino-2-(2,6-dioxo-3-piperidinyl)-6-hydroxy-(1547162-44-6) Related Product Information
Anti-cancer compound library CC-885 2-(2,6-dioxopiperidin-3-yl)-5-hydroxyisoindoline-1,3-dione (2S,4R)-1-((S)-2-amino-3,3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide L-Phenylalanine Pomalidomide