[1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-4'-[[(1R)-1,2,3,4-tetrahydro-1-methyl-1-[2-oxo-2-(2-thiazolylamino)ethyl]-6-[(tetrahydro-2H-pyran-2-yl)methoxy]-7-isoquinolinyl]oxy]-

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[1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-4'-[[(1R)-1,2,3,4-tetrahydro-1-methyl-1-[2-oxo-2-(2-thiazolylamino)ethyl]-6-[(tetrahydro-2H-pyran-2-yl)methoxy]-7-isoquinolinyl]oxy]- Basic information
Product Name:[1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-4'-[[(1R)-1,2,3,4-tetrahydro-1-methyl-1-[2-oxo-2-(2-thiazolylamino)ethyl]-6-[(tetrahydro-2H-pyran-2-yl)methoxy]-7-isoquinolinyl]oxy]-
Synonyms:[1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-4'-[[(1R)-1,2,3,4-tetrahydro-1-methyl-1-[2-oxo-2-(2-thiazolylamino)ethyl]-6-[(tetrahydro-2H-pyran-2-yl)methoxy]-7-isoquinolinyl]oxy]-;PCSK9 degrader 1
CAS:2215931-60-3
MF:C34H34FN3O6S
MW:631.71
EINECS:
Product Categories:
Mol File:2215931-60-3.mol
[1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-4'-[[(1R)-1,2,3,4-tetrahydro-1-methyl-1-[2-oxo-2-(2-thiazolylamino)ethyl]-6-[(tetrahydro-2H-pyran-2-yl)methoxy]-7-isoquinolinyl]oxy]- Structure
[1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-4'-[[(1R)-1,2,3,4-tetrahydro-1-methyl-1-[2-oxo-2-(2-thiazolylamino)ethyl]-6-[(tetrahydro-2H-pyran-2-yl)methoxy]-7-isoquinolinyl]oxy]- Chemical Properties
density 1.310±0.06 g/cm3(Predicted)
pka4.09±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
[1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-4'-[[(1R)-1,2,3,4-tetrahydro-1-methyl-1-[2-oxo-2-(2-thiazolylamino)ethyl]-6-[(tetrahydro-2H-pyran-2-yl)methoxy]-7-isoquinolinyl]oxy]- Usage And Synthesis
UsesPCSK9 ligand 1 is a selective proprotein convertase substilisin-like/kexin type 9 (PCSK9) ligand. PCSK9 ligand 1 does not affect PCSK9 function[1].
References[1] Whitney L Petrilli, et al. From Screening to Targeted Degradation: Strategies for the Discovery and Optimization of Small Molecule Ligands for PCSK9. Cell Chem Biol. 2020 Jan 16;27(1):32-40.e3. DOI:10.1016/j.chembiol.2019.10.002
[1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-4'-[[(1R)-1,2,3,4-tetrahydro-1-methyl-1-[2-oxo-2-(2-thiazolylamino)ethyl]-6-[(tetrahydro-2H-pyran-2-yl)methoxy]-7-isoquinolinyl]oxy]- Preparation Products And Raw materials
Tag:[1,1'-Biphenyl]-4-carboxylic acid, 2'-fluoro-4'-[[(1R)-1,2,3,4-tetrahydro-1-methyl-1-[2-oxo-2-(2-thiazolylamino)ethyl]-6-[(tetrahydro-2H-pyran-2-yl)methoxy]-7-isoquinolinyl]oxy]-(2215931-60-3) Related Product Information
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