L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- manufacturers
- Fosgonimeton
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2026-08-25
- CAS:2093305-05-4
- Min. Order: 50mg
- Purity: 99%
- Supply Ability: 50g
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| | L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- Basic information |
| | L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- Chemical Properties |
| density | 1.212±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C, protect from light, stored under nitrogen | | solubility | DMSO : 125 mg/mL (213.81 mM; Need ultrasonic) | | form | Solid | | pka | 1.27±0.30(Predicted) | | color | White to off-white |
| | L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- Usage And Synthesis |
| Uses | Fosgonimeton (ATH-1017) is a hepatocyte growth factor receptor (c-Met/HGFR) agonist. Fosgonimeton has neuroprotective effects in both LPS (HY-D1056) -induced neuroinflammation and Aβ-induced AD models[1][2][3][4]. | | in vivo | Fosgonimeton (0.125-2 mg/kg; Subcutaneous injection; 14 days) improves cognitive dysfunction in rat models of AD induced by Aβ[2].
Fosgonimeton (0.125-1.25 mg/kg; Subcutaneous injection; 14 days) improves cognitive impairment in a LPS (HY-D1056) -induced neuroinflammation model of dementia mice[3]. | Animal Model: | Aβ peptides treated adult male Wistar rats (approximately 210 g)[2] | | Dosage: | 0.125 mg/kg, 0.25 mg/kg, 0.5 mg/kg, 1 mg/kg and 2 mg/kg | | Administration: | Subcutaneous injection (s.c.); 14 days | | Result: | Significantly restored cognitive function at all doses tested.
The maximum average degree of recovery was 88% recovery in 0.125 mg/kg treated group.
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| Animal Model: | LPS (HY-D1056) treated CD-1 mice aged four to five weeks old[3] | | Dosage: | 0.125 mg/kg, 0.25 mg/kg, 0.5 mg/kg and 1.25 mg/kg | | Administration: | Subcutaneous injection (s.c.); 14 days | | Result: | Significantly ameliorated cognitive deficits at all doses tested, except for the lowest dose (0.125 mg/kg) tested.
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| | References | [1] Reda S, et al. Fosgonimeton, a novel, small molecule positive modulator of the HGF/MET system is neuroprotective in primary neuron culture. Alzheimer's Dement. 2022 18: e065874.
[2] Reda SM, et al. Fosgonimeton attenuates amyloid-beta toxicity in preclinical models of Alzheimer's disease. Neurotherapeutics. 2024 Jul;21(4):e00350. DOI:10.1016/j.neurot.2024.e00350
[3] Johnston JL, et al. Fosgonimeton, a Novel Positive Modulator of the HGF/MET System, Promotes Neurotrophic and Procognitive Effects in Models of Dementia. Neurotherapeutics. 2023 Mar;20(2):431-451. DOI:10.1007/s13311-022-01325-5
[4] Leen H. KAWAS, et al. WO2017210489. 2021. |
| | L-Isoleucinamide, O-(phosphono-κO)-N-(1-oxohexyl)-L-tyrosyl-N-(6-amino-6-oxohexyl)- Preparation Products And Raw materials |
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