[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester

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[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester manufacturers
[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester Basic information
Product Name:[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester
Synonyms:[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester;Boc-bipiperidine-ethynylbenzoic acid;4-((1'-(tert-Butoxycarbonyl)-[1,4'-bipiperidin]-4-yl)ethynyl)benzoic acid;4-((1'-(tert-Butoxycarbonyl)-[1,4'-bipiperidin]-4-yl)ethynyl)benzoic acid
CAS:2308497-81-4
MF:C24H32N2O4
MW:412.52
EINECS:
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Mol File:2308497-81-4.mol
[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester Structure
[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester Chemical Properties
Boiling point 557.5±50.0 °C(Predicted)
density 1.21±0.1 g/cm3(Predicted)
pka4.10±0.10(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester Usage And Synthesis
UsesBoc-bipiperidine-ethynylbenzoic acid is an Alkyl/ether-based PROTAC linker can be used in the synthesis of ARD-61[1]. Boc-bipiperidine-ethynylbenzoic acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50Alkyl/ether
References[1] Lijie Zhao, et al. A highly potent PROTAC androgen receptor (AR) degrader ARD-61 effectively inhibits AR-positive breast cancer cell growth in vitro and tumor growth in vivo. Neoplasia. 2020 Oct;22(10):522-532. DOI:10.1016/j.neo.2020.07.002
[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester Preparation Products And Raw materials
Tag:[1,4'-Bipiperidine]-1'-carboxylic acid, 4-[2-(4-carboxyphenyl)ethynyl]-, 1'-(1,1-dimethylethyl) ester(2308497-81-4) Related Product Information
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