3,4-Dimethoxy-2-Methylpyridine manufacturers
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| | 3,4-Dimethoxy-2-Methylpyridine Basic information |
| Product Name: | 3,4-Dimethoxy-2-Methylpyridine | | Synonyms: | 3,4-Dimethoxy-2-Methylpyridine;3,4-dimethoxy-2-methylpyridine (pantoprazole impurity);Pantoprazole Impurity 38;Pyridine, 3,4-dimethoxy-2-methyl- | | CAS: | 107512-35-6 | | MF: | C8H11NO2 | | MW: | 153.18 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File |  |
| | 3,4-Dimethoxy-2-Methylpyridine Chemical Properties |
| Boiling point | 211.7±35.0 °C(Predicted) | | density | 1.042±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | pka | 7.85±0.10(Predicted) | | Appearance | Colorless to light yellow Liquid |
| | 3,4-Dimethoxy-2-Methylpyridine Usage And Synthesis |
| Synthesis | General procedure: 38 g of 3-hydroxy-2-methylpyridin-4(1H)-one was added to a reaction flask and dissolved in a mixed solution of 90 g of water and 35 g of potassium hydroxide with stirring. The reaction temperature was controlled at 10~20°C. 75 g of dimethyl sulfate was slowly added dropwise, and the reaction was held at the same temperature for 20 hours after the dropwise addition. After completion of the reaction, 80 g of dichloromethane was added to the reaction mixture, stirred for 15 minutes and left to stratify. The aqueous layer was extracted once more with 20 g of dichloromethane, stirred for 15 minutes and left to stratify. The two dichloromethane layers were combined and concentrated under reduced pressure. The product was dried under reduced pressure to give 44 g of 3,4-dimethoxy-2-methylpyridine. | | References | [1] Patent: CN104557692, 2018, B. Location in patent: Paragraph 0030; 0031 |
| | 3,4-Dimethoxy-2-Methylpyridine Preparation Products And Raw materials |
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