1H-Benzimidazole-2-propanol, 5,7-dichloro-6-(4,4-difluoro-1-piperidinyl)-γ-[4-(ethylsulfonyl)phenyl]-, (γR)-

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1H-Benzimidazole-2-propanol, 5,7-dichloro-6-(4,4-difluoro-1-piperidinyl)-γ-[4-(ethylsulfonyl)phenyl]-, (γR)- Basic information
Product Name:1H-Benzimidazole-2-propanol, 5,7-dichloro-6-(4,4-difluoro-1-piperidinyl)-γ-[4-(ethylsulfonyl)phenyl]-, (γR)-
Synonyms:1H-Benzimidazole-2-propanol, 5,7-dichloro-6-(4,4-difluoro-1-piperidinyl)-γ-[4-(ethylsulfonyl)phenyl]-, (γR)-;SHR168442
CAS:2382961-86-4
MF:C23H25Cl2F2N3O3S
MW:532.43
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Product Categories:
Mol File:2382961-86-4.mol
1H-Benzimidazole-2-propanol, 5,7-dichloro-6-(4,4-difluoro-1-piperidinyl)-γ-[4-(ethylsulfonyl)phenyl]-, (γR)- Structure
1H-Benzimidazole-2-propanol, 5,7-dichloro-6-(4,4-difluoro-1-piperidinyl)-γ-[4-(ethylsulfonyl)phenyl]-, (γR)- Chemical Properties
Boiling point 777.0±60.0 °C(Predicted)
density 1.50±0.1 g/cm3(Predicted)
pka9.55±0.30(Predicted)
Safety Information
MSDS Information
1H-Benzimidazole-2-propanol, 5,7-dichloro-6-(4,4-difluoro-1-piperidinyl)-γ-[4-(ethylsulfonyl)phenyl]-, (γR)- Usage And Synthesis
UsesSHR168442 is a modulator of retinoid-related orphan receptor gamma (RORγ) with an IC50 value of 0.035 μM.
IC 50ROR-γ
References[1] Yan Y, et al. Benzimidazole derivatives as modulators of retinoid-related orphan receptor gamma (ror) and pharmaceutical uses thereof. WO2019213470 A1.
1H-Benzimidazole-2-propanol, 5,7-dichloro-6-(4,4-difluoro-1-piperidinyl)-γ-[4-(ethylsulfonyl)phenyl]-, (γR)- Preparation Products And Raw materials
Tag:1H-Benzimidazole-2-propanol, 5,7-dichloro-6-(4,4-difluoro-1-piperidinyl)-γ-[4-(ethylsulfonyl)phenyl]-, (γR)-(2382961-86-4) Related Product Information
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