| Company Name: |
Shanghai Biolang biotechnology Co.,Ltd
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| Tel: |
17764003753 |
| Email: |
2326587775@qq.com |
| Products Intro: |
Product Name:Tofersen
CAS:2088232-70-4
Purity:99% HPLC Package:100MG， 1G, 10G, 1KG
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| | BIIB067 Basic information |
| | BIIB067 Chemical Properties |
| storage temp. | -20°C, stored under nitrogen | | form | Solid | | color | Off-white to light yellow | | Water Solubility | Water : 100 mg/mL (14.03 mM; Need ultrasonic) | | Sequence | DNA, d([2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]rA-[2'-O-(2- methoxyethyl)]rG-sp-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]rA-sp-Tsp-A-sp-m5C-sp-A-sp-T-sp-T-sp-T-sp-m5C-sp-T-sp-A-sp-[2'-O-(2-methoxyethyl)]m5rC-[2'-O-(2-methoxyethyl)]rA-sp-[2'-O-(2-methoxyethyl)]rG-[2'-O-(2-methoxyethyl)]m5rC-sp-[2'-O-(2-methoxyethyl)]m5rU) |
| | BIIB067 Usage And Synthesis |
| Uses | Tofersen (BIIB067) is an antisense oligonucleotide that mediates RNase H-dependent degradation of superoxide dismutase 1 (SOD1) mRNA to reduce the synthesis of SOD1 protein. Tofersen can be used for the research of amyotrophic lateral sclerosis (ALS)[1]. | | References | [1] Miller T, et, al. Phase 1-2 Trial of Antisense Oligonucleotide Tofersen for SOD1 ALS. N Engl J Med. 2020 Jul 9;383(2):109-119. DOI:10.1056/NEJMoa2003715
[2] McCampbell A, et, al. Antisense oligonucleotides extend survival and reverse decrement in muscle response in ALS models. J Clin Invest. 2018 Aug 1;128(8):3558-3567. DOI:10.1172/JCI99081 |
| | BIIB067 Preparation Products And Raw materials |
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