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| | N-Biotinylaminoethyl Methanethiosulfonate Basic information |
| Product Name: | N-Biotinylaminoethyl Methanethiosulfonate | | Synonyms: | N-Biotinylaminoethyl methylthiosulphonate;Methanesulfonothioic Acid S-[2-[[5-[(3aS,4S,6aR)-Hexahydro-2-oxo-1H-thieno[3,4-d]iMidazol-4-yl]-1-oxopentyl]aMino]ethyl] Ester;2-[(Biotinoyl)-amino]-ethyl-methanthiosulfonat;O-(2-(5-((3AS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl)pentanamido)ethyl) methanesulfonothioate;MTSEA-Biotin [N-Biotinoylaminoethyl methanethiosulfonate;N-(1-((2R,3R,4R,5S)-5-(hydroxymethyl)-3-(2-methoxyethoxy)-4-(((4-methoxyphenyl)diphenylmethyl)amino)tetrahydrofuran-2-yl)-2-oxo-1,2-dihydropyrimidin-4-yl)benzamide | | CAS: | 162758-04-5 | | MF: | C13H23N3O4S3 | | MW: | 381.54 | | EINECS: | | | Product Categories: | Biotin Derivatives;Cross Linking Reagents;MTS & Sulfhydryl Active Reagents | | Mol File: | 162758-04-5.mol |  |
| | N-Biotinylaminoethyl Methanethiosulfonate Chemical Properties |
| Melting point | 95-103°C | | Boiling point | 779.885±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.322±0.06 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | storage temp. | -20°C Freezer, Under Inert Atmosphere | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml | | form | A crystalline solid | | pka | 13.896±0.40(predicted) | | Stability: | Moisture Sensitive | | InChI | InChI=1S/C13H23N3O4S3/c1-23(19,20)22-7-6-14-11(17)5-3-2-4-10-12-9(8-21-10)15-13(18)16-12/h9-10,12H,2-8H2,1H3,(H,14,17)(H2,15,16,18)/t9-,10-,12-/m0/s1 | | InChIKey | CQPWMXNDGWWWHG-NHCYSSNCSA-N | | SMILES | CS(SCCNC(=O)CCCC[C@H]1[C@@]2([H])NC(=O)N[C@@]2([H])CS1)(=O)=O |
| | N-Biotinylaminoethyl Methanethiosulfonate Usage And Synthesis |
| Description | MTSEA-biotin is a thiol-reactive probe that can be used to label proteins at cysteine residues. | | Chemical Properties | White Fluffy Solid | | Uses | Reacts specifically and rapidly with thiols to form mixed disulfides. N-Biotinylaminoethyl Methanethiosulfonate can be used to probe the structures of the ACh receptor channel of the GABA receptor channel and of lactose permease. MTSEA-biotin has recently been used to probe the topology of the serotonin (5-HT) transporter by site-directed chemical labelling. | | References | [1] D. WAGNER C C. Structure and Dynamics of the GABA Binding Pocket: A Narrowing Cleft that Constricts during Activation[J]. The Journal of Neuroscience, 2001, 76 1: 67-74. DOI: 10.1523/jneurosci.21-01-00067.2001
[2] MING ZHONG. Vitamin A transport and the transmembrane pore in the cell-surface receptor for plasma retinol binding protein.[J]. PLoS ONE, 2013: e73838. DOI: 10.1371/journal.pone.0073838 |
| | N-Biotinylaminoethyl Methanethiosulfonate Preparation Products And Raw materials |
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