3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- manufacturers
- PY-60
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- $123.00
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2026-07-27
- CAS:2765218-56-0
- Purity: 99.67%
- Supply Ability: 10g
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| | 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- Basic information |
| | 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- Chemical Properties |
| Boiling point | 559.1±45.0 °C(Predicted) | | density | 1.266±0.06 g/cm3(Predicted) | | storage temp. | -10 to -25°C | | solubility | DMSO: 2mg/mL, clear | | form | Solid | | pka | 13.06±0.46(Predicted) | | color | White to off-white |
| WGK Germany | WGK 3 | | Storage Class | 11 - Combustible Solids |
| | 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- Usage And Synthesis |
| Description | PY-60 is a novel activator of YAP, promoting expansion of epidermal keratinocytes ex vivo and in vivo, targeting ANXA2 to activate YAP, activating a robust, YAP- dependent transcriptional program in multiple cell types. Chemical proteomics revealed the relevant target of PY-60 to be annexin A2 (ANXA2), a protein that directly associates with YAP at the cell membrane in response to increased cell density. PY-60 treatment liberates ANXA2 from the membrane, ultimately promoting a phosphatase-bound, nonphosphorylated and transcriptionally active form of YAP. | | Uses | PY-60 is a robust and specific activator of YAP transcriptional activity that targets annexin A2 (ANXA2) with a Kd of 1.4 μM. PY-60 directly binds to ANXA2 and antagonizes its normal cellular function of repressing YAP activity[1]. | | in vivo | PY-60 (10 uM; applied topically to the dorsal skin of wild-type adult C57BL/6 mice over the course of 10 days) promotes a dramatic expansion of keratinocytes and K14-positive precursors, as assessed by hematoxylin and eosin and anti-K14 histological staining at the study end. PY-60 results in an approximate doubling of epidermal thickness, a result derived from an increased number of keratinocytes per unit length of skin[1]. | | References | [1] Shalhout SZ, et al. YAP-dependent proliferation by a small molecule targeting annexin A2. Nat Chem Biol. 2021;17(7):767-775. DOI:10.1038/s41589-021-00755-0 |
| | 3-Isoxazolecarboxamide, 5-phenyl-N-[3-(2-thiazolyl)propyl]- Preparation Products And Raw materials |
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