阿夫立定
| 中文名称 | 阿夫立定 |
|---|---|
| 中文同义词 | 阿夫立定;化合物 T15003;化合物 CP-20961 |
| 英文名称 | Avridine |
| 英文同义词 | 2,2'-[[3-(Dioctadecylamino)propyl]imino]bisethanol;2,2'-[[3-(Dioctadecylamino)propyl]imino]diethanol;CP-20961;N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)-1,3-diaminopropane;Avridine;N,N-Dioctadecyl-N',N'-bis(2-hydroxyethyl)propanediaMine;N,N-dioctadecyl-N',N'-bis(2-hydroxyethyl)1,3-propanediamine;CP 20961,CP20961 |
| CAS号 | 35607-20-6 |
| 分子式 | C43H90N2O2 |
| 分子量 | 667.19 |
| EINECS号 | |
| 相关类别 | Aliphatics;Amines;Intermediates & Fine Chemicals;Pfizer Compounds;Pharmaceuticals |
| Mol文件 | 35607-20-6.mol |
| 结构式 |  |
阿夫立定 性质
| 熔点 | 39-40°C |
|---|---|
| 沸点 | 717.6±40.0 °C(Predicted) |
| 密度 | 0.892±0.06 g/cm3(Predicted) |
| 储存条件 | Store at RT |
| 溶解度 | DMSO：≥5mg/mL（升温至 60°C 5 分钟） |
| 酸度系数(pKa) | 14.41±0.10(Predicted) |
| 形态 | 粉末 |
| 颜色 | 白色至类白色 |
| InChIKey | WXNRAKRZUCLRBP-UHFFFAOYSA-N |
| SMILES | CCCCCCCCCCCCCCCCCCN(CCCCCCCCCCCCCCCCCC)CCCN(CCO)CCO |
CP-20961 是有效的、合成的无免疫原性的、可诱导关节炎的佐剂。
Avridine-induced arthritis is severe and long lasting in LEW and DA rats.
CP-20961 (10 mg/kg, i.v., once either 24, 48, or 72 hours post-burn) had no effect on survival after challenge with
P. aeruginosa
96 hours post-burn.
| Animal Model: | Female, Hartley-derived guinea pigs, weighing 350 to 400 g. |
| Dosage: | 10 mg/kg. |
| Administration: | IV once either 24, 48, or 72 hours post-burn. |
| Result: | Had no effect on survival after challenge with P. aeruginosa 96 hours post-burn. |
安全信息
| WGK Germany | 3 |
|---|---|
| RTECS号 | KK7243000 |
| 存储类别 | 11 - 可燃固体 |
上游原料