1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-

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1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- Suppliers list
Company Name: Guangzhou Younan Technology Co., Ltd  
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Company Name: TargetMol Chemicals Inc.  
Tel: 15002134094
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Company Name: TargetMol Chemicals Inc.  
Tel: 13564774135
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1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- manufacturers

  • Rohinitib
  • Rohinitib pictures
  • 2026-05-11
  • CAS:1139253-73-8
  • Purity:
  • Supply Ability: 10g
1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- Basic information
Product Name:1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-
Synonyms:1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-;Rohinitib
CAS:1139253-73-8
MF:C29H31NO8
MW:521.56
EINECS:
Product Categories:
Mol File:1139253-73-8.mol
1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- Structure
1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- Chemical Properties
Boiling point 646.3±65.0 °C(Predicted)
density 1.340±0.06 g/cm3(Predicted)
pka11.63±0.70(Predicted)
form Solid
color White to off-white
Safety Information
MSDS Information
1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- Usage And Synthesis
DescriptionRohinitib is a HSF1 inhibitor for target-based cancer therapy.
UsesRohinitib is a potent and specific eIF4A inhibitor. Rohinitib induces cell apoptosis of acute myeloid leukemia (AML) cell lines and reduces the leukemia burden of AML xenograft model. Rohinitib can be used for the research of AML[1].
in vivo

Rohinitib (0.75 and 1.0 mg/kg; s.c. once daily for 5 consecutive days until mice get moribund) shows anti-AML effects in vivo[1].

Animal Model:Female NSG mice with AML xenografts generated by intravenous injections of MOLM-13 cells[1]
Dosage:0.75 and 1.0 mg/kg
Administration:Subcutaneous injection; 0.75 and 1.0 mg/kg once daily 5 days a week until mice get moribund
Result:Significantly reduced the leukemia burden, circulating and BM leukemic human CD45+ cells. Dose-dependently prolonged the survival rate of mice.
References[1] Nishida Y, et alJ. Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML. Leukemia. 2021 Sep;35(9):2469-2481. DOI:10.1038/s41375-021-01308-z
1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- Preparation Products And Raw materials
Tag:1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)-(1139253-73-8) Related Product Information
1H-Cyclopenta[b]benzofuran-2-carboxamide, 6-cyano-2,3,3a,8b-tetrahydro-1,8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-N,N-dimethyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- CMLD010509 1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-6,8-dimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, (1R,2R,3S,3aR,8bS)- 1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-3-phenyl-, (1S,2S,3R,3aS,8bR)- 1H-Cyclopenta[b]benzofuran-2-carboxamide, 2,3,3a,8b-tetrahydro-1,8b-dihydroxy-N,6,8-trimethoxy-3a-(4-methoxyphenyl)-N-methyl-3-phenyl-, (1R,2R,3S,3aR,8bS)- 3'-Hydroxyrocaglamide