Rooperol manufacturers
- Rooperol
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- $1520.00
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2026-05-11
- CAS:83644-00-2
- Purity:
- Supply Ability: 10g
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| | Rooperol Basic information |
| | Rooperol Chemical Properties |
| | Rooperol Usage And Synthesis |
| Description | Rooperol is a norlignan derivative with numerous biological activities including immunomodulatory, antitumor, anticonvulsant, antibacterial, and antioxidant activities. It has been identified as a novel p38α inhibitor. | | Uses | Rooperol is a norlignan analog with antitumor, anti-inflammatory, and antioxidant activities. Rooperol induces apoptosis in CSCs through a mitochondrial-induced increase in ROS and a p53-dependent pathway, while also downregulating the expression of key stem cell regulatory factors, such as Oct4, Nanog, and Sox2, ultimately exerting its anticancer effects[1][2][3][4]. | | References | [1] Boukes G J, et al. Rooperol as an antioxidant and its role in the innate immune system: An in vitro study[J]. Journal of ethnopharmacology, 2012, 144(3): 692-699. DOI:10.1016/j.jep.2012.10.014
[2] Kabanda M M. Antioxidant activity of rooperol investigated through Cu (I and II) chelation ability and the hydrogen transfer mechanism: a DFT study[J]. Chemical research in toxicology, 2012, 25(10): 2153-2166. DOI:10.1021/tx300244z
[3] Guzdek A, et al. Rooperol, an inhibitor of cytokine synthesis, decreases the respiratory burst in human and rat leukocytes and macrophages[J]. Mediators of Inflammation, 1997, 6(1): 53-57. DOI:10.1080/09629359791938
[4] Ali Azouaou S, et al. Selective ROS-dependent p53-associated anticancer effects of the hypoxoside derivative rooperol on human teratocarcinomal cancer stem-like cells[J]. Investigational New Drugs, 2015, 33: 64-74. DOI:10.1007/s10637-014-0182-6 |
| | Rooperol Preparation Products And Raw materials |
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