1,18-Etheno-4H-pyrido[4,3-e]pyrimido[1,6-g][1,7,9]benzotriazacyclododecin-4-one, 17,20-difluoro-10,11,12,13-tetrahydro-6-(1-methylethyl)-2-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-

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1,18-Etheno-4H-pyrido[4,3-e]pyrimido[1,6-g][1,7,9]benzotriazacyclododecin-4-one, 17,20-difluoro-10,11,12,13-tetrahydro-6-(1-methylethyl)-2-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Basic information
Product Name:1,18-Etheno-4H-pyrido[4,3-e]pyrimido[1,6-g][1,7,9]benzotriazacyclododecin-4-one, 17,20-difluoro-10,11,12,13-tetrahydro-6-(1-methylethyl)-2-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-
Synonyms:1,18-Etheno-4H-pyrido[4,3-e]pyrimido[1,6-g][1,7,9]benzotriazacyclododecin-4-one, 17,20-difluoro-10,11,12,13-tetrahydro-6-(1-methylethyl)-2-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-;KRAS G12C inhibitor 46
CAS:2573769-23-8
MF:C32H33F2N7O2
MW:585.65
EINECS:
Product Categories:
Mol File:2573769-23-8.mol
1,18-Etheno-4H-pyrido[4,3-e]pyrimido[1,6-g][1,7,9]benzotriazacyclododecin-4-one, 17,20-difluoro-10,11,12,13-tetrahydro-6-(1-methylethyl)-2-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Structure
1,18-Etheno-4H-pyrido[4,3-e]pyrimido[1,6-g][1,7,9]benzotriazacyclododecin-4-one, 17,20-difluoro-10,11,12,13-tetrahydro-6-(1-methylethyl)-2-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Chemical Properties
Boiling point 771.6±70.0 °C(Predicted)
density 1.38±0.1 g/cm3(Predicted)
pka5.04±0.40(Predicted)
Safety Information
MSDS Information
1,18-Etheno-4H-pyrido[4,3-e]pyrimido[1,6-g][1,7,9]benzotriazacyclododecin-4-one, 17,20-difluoro-10,11,12,13-tetrahydro-6-(1-methylethyl)-2-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Usage And Synthesis
UsesKRAS G12C inhibitor 46 (compound WX003) is a potent KRAS G12C inhibitor[1].
IC 50KRas G12C
References[1] Li Qiu, et al. Macrocyclic compoung serving as Kras inhibitor. WO2021147967A1.
1,18-Etheno-4H-pyrido[4,3-e]pyrimido[1,6-g][1,7,9]benzotriazacyclododecin-4-one, 17,20-difluoro-10,11,12,13-tetrahydro-6-(1-methylethyl)-2-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]- Preparation Products And Raw materials
Tag:1,18-Etheno-4H-pyrido[4,3-e]pyrimido[1,6-g][1,7,9]benzotriazacyclododecin-4-one, 17,20-difluoro-10,11,12,13-tetrahydro-6-(1-methylethyl)-2-[(2S)-2-methyl-4-(1-oxo-2-propen-1-yl)-1-piperazinyl]-(2573769-23-8) Related Product Information
2-Propen-1-one, 1-[(3S)-4-[(7R)-7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2-[[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl]- 2,7-Diazaspiro[4.4]nonane-2-acetamide, α-cyclopentyl-7-[[(2R,3R)-3-cyclopropyl-1-methyl-2-aziridinyl]carbonyl]-N-[(1R,10S,12S,18S)-1-[5-(4-cyclopropyl-1-piperazinyl)-2-[(1S)-1-methoxyethyl]-3-pyridinyl]-2,7,8,10,11,12,13,16,17,18,19,21,22,23-tetradecahydro-22,22-dimethyl-13,19-dioxo-2-(2,2,2-trifluoroethyl)-15H-3,5-etheno-14,18-imino-6,10-methano-6H-pyrrolo[3,4-g][1,12,4,18]dioxadiazacyclodocosin-12-yl]-, (αS,5S)- 1,4-Oxazepin-5(2H)-one, 4-[3-[[2-[[2-ethyl-4-(4-methyl-1-piperazinyl)phenyl]amino]-5-(trifluoromethyl)-4-pyrimidinyl]amino]propyl]tetrahydro- RMC6291 RMC5127 RMC6236