2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)-

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2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- manufacturers

  • JC2-11
  • JC2-11 pictures
  • $38.00
  • 2026-07-27
  • CAS:937820-89-8
  • Purity: 99.88%
  • Supply Ability: 10g
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- Basic information
Product Name:2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)-
Synonyms:2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)-;JC2-11;(2E)-1-(3-Fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-2-propen-1-one;(E)-1-(3-Fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)prop-2-en-1-one;JC2-11, 10 mM in DMSO
CAS:937820-89-8
MF:C17H15FO4
MW:302.3
EINECS:
Product Categories:
Mol File:937820-89-8.mol
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- Structure
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- Chemical Properties
Boiling point 482.0±45.0 °C(Predicted)
density 1.257±0.06 g/cm3(Predicted)
solubility DMSO: Sparingly soluble: 1-10 mg/ml
form Solid
pka9.67±0.31(Predicted)
color Off-white to yellow
Safety Information
MSDS Information
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- Usage And Synthesis
UsesJC2-11 is an inhibitor of inflammatory corpuscles. JC2-11 inhibits domain-containing protein NLRC 4, absent in melanoma 2 (AIM 2) and non-canonical (NC) inflammatory corpuscles. JC2-11 reduces the secretion of caspase-1 (p20), the cleavage of gasdermin D (GSDMD), and the releases of IL-1β and lactate dehydrogenases (LDH) in inflammatory bodies. JC2-11 inhibits the activation of inflammatory bodies by destroying the production of reactive oxygen species and the activity of caspase-1[1].
in vivo

JC2-11 (250 μg/mouse; i.p.; single dose) significantly inhibits the release of caspase-1 (p20) and IL-1β in non-canonical (NC) inflammatory bodies, and weakens the activation of NC inflammatory bodies of C57BL/6 mice model[1].

Animal Model:C57BL/6 mice (8 weeks, female)[1].
Dosage:250 μg/mouse.
Administration:Intraperitoneal injection; single dose.
Result:Exhibited inhibitory effect on NC inflammatory body.
IC 50NLRP3 inflammasome
References[1] Lee G, et al, JC2-11, a benzylideneacetophenone derivative, attenuates inflammasome activation. Sci Rep. 2022 Dec 28;12(1):22484. DOI:10.1038/s41598-022-27129-3
[2] SOYONG JANG  Seikwan O  Jae Chul Jung. Synthesis of 1,3-diphenyl-2-propen-1-one derivatives and evaluation of their biological activities[J]. Bioorganic & Medicinal Chemistry, 2007, 15 12: Pages 4098-4105. DOI: 10.1016/j.bmc.2007.03.077
2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)- Preparation Products And Raw materials
Tag:2-Propen-1-one, 1-(3-fluoro-4-methoxyphenyl)-3-(4-hydroxy-3-methoxyphenyl)-, (2E)-(937820-89-8) Related Product Information
Chalcone, 5'-fluoro-2',4-dihydroxy-3-methoxy- (7CI,8CI) (2E)-1-(4-ethylphenyl)-3-(3,4,5-trimethoxyphenyl)prop-2-en-1-one 2-Propen-1-one, 1-(5-fluoro-2-hydroxyphenyl)-3-(4-methoxyphenyl)- 3,4-Dimethoxychalcone (2E)-3-(3,4-dimethoxyphenyl)-1-(3-methoxyphenyl)prop-2-en-1-one 2-Propen-1-one, 3-phenyl-1-(3,4,5-trimethoxyphenyl)-