Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)-

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Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)- Suppliers list
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Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)- manufacturers

  • HR-19011
  • HR-19011 pictures
  • $76.00
  • 2025-12-27
  • CAS:2851820-52-3
  • Purity: 99.89%
  • Supply Ability: 10g
Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)- Basic information
Product Name:Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)-
Synonyms:Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)-;3-((3,4-Dioxo-2-((trans-4-(4-(trifluoromethyl)phenoxy)cyclohexyl)amino)cyclobut-1-en-1-yl)amino)-5-(trifluoromethyl)benzonitrile;HR-19011
CAS:2851820-52-3
MF:C25H19F6N3O3
MW:523.43
EINECS:
Product Categories:
Mol File:2851820-52-3.mol
Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)- Structure
Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)- Chemical Properties
Boiling point 561.4±60.0 °C(Predicted)
density 1.47±0.1 g/cm3(Predicted)
pka-0.44±0.20(Predicted)
form Solid
color White to yellow
Safety Information
MSDS Information
Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)- Usage And Synthesis
UsesEIF2α activator 1 (Compound 40) is an activator of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. EIF2α activator 1 increases the expression level of eIF2α downstream proteins, ATF and CHOP. EIF2α activator 1 exhibits antiproliferative activity againist K562 and PBMC cells with IC50s of 4.00 and 19.3 μM, respectively[1].
IC 50eIF2
References[1] Jinsook Kwak, et al. A bioisosteric approach to the discovery of novel N-aryl-N'-[4-(aryloxy)cyclohexyl]squaramide-based activators of eukaryotic initiation factor 2 alpha (eIF2α) phosphorylation. Eur J Med Chem. 2022 May 29;239:114501. DOI:10.1016/j.ejmech.2022.114501
Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)- Preparation Products And Raw materials
Tag:Benzonitrile, 3-[[3,4-dioxo-2-[[trans-4-[4-(trifluoromethyl)phenoxy]cyclohexyl]amino]-1-cyclobuten-1-yl]amino]-5-(trifluoromethyl)-(2851820-52-3) Related Product Information
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