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bucainide

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bucainide Basic information
Product Name:bucainide
Synonyms:Bucainide maleate
CAS:51481-63-1
MF:C29H43N3O8
MW:561.66702
EINECS:
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Mol File:51481-63-1.mol
bucainide Structure
bucainide Chemical Properties
Safety Information
MSDS Information
bucainide Usage And Synthesis
OriginatorBucainide maleate,ZYF Pharm Chemical
UsesCardiac depressant (anti-arrhythmic).
Manufacturing ProcessTo a solution of 13.6 g (0.08 mol) of N-hexylpiperazine and 8.1 g (11.2 ml), (0.08 mol) of triethylamine in 120 ml toluene, was added 15.6 g (0.08 mol) of N-isobutyl-benzimidoyl chloride over a period of 15 minutes. The reaction mixture was stirred at room temperature for a period of 2 hours. The triethylamine hydrochloride was filtered off and the filtrate concentrated under vacuum. The residual oily base was washed with 20 ml water, extracted with 50 ml ether and dried over anhydrous magnesium sulfate. The dry ethereal solution was then added to a solution of 18.6 g (0.16 mol) maleic acid in 800 ml ether to obtain the dimaleate salt. Two recrystallizations from ethanol yielded 22.5 g (50.2%) of N-[(4-hexyl-1-piperazinyl)phenylmethylene]-2- methyl-1-propanamine product, M.P. 175°-176°C.
Therapeutic FunctionAntiarrhythmic
bucainide Preparation Products And Raw materials
Raw materialsMaleic acid
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